CONCLUSION--A pattern of atrophy in the frontal lobes and hippocampal formation with sparing of the medial temporal lobe might be distinctive of frontotemporal dementia. Hippocampal involvement might not be specific for Alzheimer's disease and specific patterns of atrophy might be distinctive of some ...
We present the unusual case of a patient whose frontal defect was not reconstructed for 9 years and who, as a result, developed frontal lobe atrophy and subsequent severe psychologic and behavioral difficulties. 展开 关键词: Keywords Brain atrophy frontal bone loss monobloc ...
Importantly, TDP-43-associated rates of brain atrophy are non-linear over the course of the disease (Josephs et al., 2020). There is still, however, a void in our understanding of how neurodegeneration in FTLD-TDP compares to AD-TDP and pure-TDP, longitudinally. While FTLD-TDP is sub...
In this study, we aimed to determine the progression of brain atrophy in the parkinson variant of multiple system atrophy (MSA-P). Voxel-based morphometry was applied to two consecutive high resolution MR images of 14 patients with probable MSA-P in comparison to 14 patients with Parkinson’s...
Using the left frontal lobe as an exemplar, in the presymptomatic stage, MAPT mutation carriers showed the greatest rate of atrophy compared to controls (88 mm3/year more volume loss than controls), followed by GRN+ (65 mm3/year) and then C9orf72+ (49 mm3/year). In the mild/...
Inflammation is an important factor in Alzheimer’s disease (AD). An NMR measurement in plasma, glycoprotein acetyls (GlycA), captures the overall level of protein production and glycosylation implicated in systemic inflammation. With its additional adva
The brain damage exhibited in AD mainly occurs in the medial temporal lobe, particularly the hippocampus and entorhinal cortex. Conversely, FTD is distinguished from AD by frontal lobe damage [5]. Investigating the pathologic characteristics of these two MCI subtypes is crucial for successful early ...
Regional brain atrophy in progressive supranuclear palsy and Lewy body disease Patients with Parkinson's disease had atrophy confined to the amygdala. Atrophy of the frontal lobe was found in both PSP and dementia with Lewy bodies ... N. J. Cordato FRACP,G. M. Halliday PhD,A. J. Harding...
The purposes of this study were (1) to assess episodic memory function in FTLD, and more specifically patients' ability to episodically re-experience an event, and determine its source; (2) to examine whether memory performance is related to quantified regional brain atrophy. FTLD patients (=18...
Non-parametric concordance/discordance tests revealed that GM atrophy without hypoperfusion occurs in the premotor cortex in FTD whereas concordant GM atrophy and hypoperfusion changes are found in the right prefrontal cortex and bilateral medial frontal lobe. The results suggest that damage of brain ...