Among the 125 (88%) infants who received a brain MRI at ≤8 days, mild (44%) injury was more common than moderate (11%) or severe (4%) injury. Subacute (37%) lesions were more commonly observed than acute (32%) or chronic lesions (1%).Subacute brain injury is common in newborn...
CLINICAL RESEARCH ARTICLE OPENMild hypoxic-ischemic encephalopathy (HIE): timing andpattern of MRI brain injuryYi Li 1 ✉ , Jessica L. Wisnowski 2 , Lina Chalak 3 , Amit M. Mathur 4 , Robert C. McKinstry 5 , Genesis Licona 6 , Dennis E. Mayock 7 , Taeun Chang 8 ,Krisa P. ...
Aging, neurodegenerative processes and ischemic vascular mechanisms all contribute to cerebral structural changes as longevity increases and, interactively, may enhance in progressive cognitive decline, with a continuum from normal aging, via MCI, to dementia, among elderly populations worldwide [9], [12...
Asthma is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness, and underlying inflammation. Allergic asthma is the most common form of asthma, with symptoms triggered by inhaled allergens.30 miR-21 regulates polarized adaptive...
This study utilizes 3.0T MRI for high-resolution imaging of carotid artery plaques, aiming to analyze and compare the relationship between ischemic events and plaque burden based on an understanding of plaque composition. Additionally, the study explores the correlation between these factors and cerebral...
The non-ischemic LGE pattern resembles the changes frequently observed in chronic systemic inflammatory conditions22, where increased vascular stiffness is well-established23. The latter conditions tend to be more frequent in females, potentially explaining the higher proportion of symptomatic females after...
Brain magnetic resonance imaging (MRI) 3T showed multiple small oval T2 hyperintensities in deep and subcortical white matter of left frontal region, left insula and subcortical white matter of the right frontal region, most likely chronic vascular lesions. Mild brain atrophy was present with no ...
In addition to the pathological phospho-tau found at chronic time points after injury, we also found evidence of white matter damage at 20 w post-rmTBI. The ultrastructural changes in the white matter included a decrease in myelin thickness and a decrease in the percentage of axons that were...
Modified Hachinski Ischemic Scale score ≤ 4 8. Formal education for eight or more years 9. Previous decline in cognition for more than 6 months (based on patient medical records) 10. A caregiver living in the same household or interacting with the participant for a sufficient amount ...
Abbreviations: SD, standard deviation; BMI, body mass index; ADCS-CGIC, Alzheimer's Disease Cooperative Study–Clinical Global Impression of Change; MMSE, Mini–Mental State Examination; HIS, Hachinski Ischemic Score; CDR, Clinical Dementia Rating. ∗ The enrolled patients were free of psychiatric...