Among the 125 (88%) infants who received a brain MRI at ≤8 days, mild (44%) injury was more common than moderate (11%) or severe (4%) injury. Subacute (37%) lesions were more commonly observed than acute (32%) or chronic lesions (1%).Subacute brain injury is common in newborn...
CLINICAL RESEARCH ARTICLE OPENMild hypoxic-ischemic encephalopathy (HIE): timing andpattern of MRI brain injuryYi Li 1 ✉ , Jessica L. Wisnowski 2 , Lina Chalak 3 , Amit M. Mathur 4 , Robert C. McKinstry 5 , Genesis Licona 6 , Dennis E. Mayock 7 , Taeun Chang 8 ,Krisa P. ...
The non-ischemic LGE pattern resembles the changes frequently observed in chronic systemic inflammatory conditions22, where increased vascular stiffness is well-established23. The latter conditions tend to be more frequent in females, potentially explaining the higher proportion of symptomatic females after...
Asthma is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness, and underlying inflammation. Allergic asthma is the most common form of asthma, with symptoms triggered by inhaled allergens.30 miR-21 regulates polarized adaptive...
Thus, MIUH has a deleterious impact, mainly in the placenta, on the levels of proteins related to inflammation and ischemic/vascular injury. mRNA expression in the fetal brain. To investigate the damage that MIUH may cause to immature neural cells, the mRNA expression of nestin (an ...
chronic inflammatory bowel disease, chronic or frequent diarrhea or loose stools, history of GI surgery that resulted in malabsorption, vitamin B12 or folate deficiency, hematologic or solid malignant tumor diagnoses within 5 years, Geriatric Depression Scale score of 6 or higher at screening, or exp...
MRI scans were usable in 1906. Some information on cognitive status was available on another 3743 individuals through either TICSm (n = 1461), an informant interview (n = 505), or information from hospital discharge or death codes recorded during the time frame of ARIC-NCS (n = 1777). ...
lower levels of CRP could be beneficial to older adults with MCI. One prior study has suggested that CRP is directly involved in the pathogenesis of atherogenesis and ischemic cerebrovascular diseases, contributing to the development of pathologies in the vasculature, a hallmark of vascular dementia ...
Aging, neurodegenerative processes and ischemic vascular mechanisms all contribute to cerebral structural changes as longevity increases and, interactively, may enhance in progressive cognitive decline, with a continuum from normal aging, via MCI, to dementia, among elderly populations worldwide [9], [12...
MRI: Magnetic resonance imaging MS: Mass spectrometry NfL: Neurofilament light NHW: Non-Hispanic White P-tau181: Phosphorylated tau at Threonine (Thr) 181 sTREM2: Soluble TREM2 TFA: Trifluoroacetic acid Thr: Threonine TIA: Transient ischemic attack T-tau: Total tau WHO: World he...