Furthermore, we have identified MIF as the major trigger for MSC homing, being secreted from tumour cells at high levels. For the first time, we have identified in this study a novel axis: MIF-CXCR4, showing a physical interaction between them and validating their essential role in vitro ...
(CXCR4)在As中发挥着重要的作用.CXCL12-CXCR4生物轴是一条重要的趋化因子/趋化因子受体轴,能够调控细胞增殖,动员,分化,归巢和趋化等多种生物学行为,大量研究发现其广泛影响着与As相关的多种细胞,与As斑块的形成,发展密切相关.因此,CXCL12/MIF-CXCR4生物轴有望成为更加精确的As治疗靶点,调控CXCL12/MIF-CXCR4生物...
基金 国家自然科学基金青年基金项目(82200543) 江苏省卫生健康委医学科研项目(ZD2021056)。 关键词 CXCL12/MIF-CXCR4生物轴 巨噬细胞迁移抑制因子 动脉粥样硬化 CXCL12/MIF-CXCR4 bioaxis macrophage migration inhibition factor atherosclerosis 分类号 R5 [医药卫生—内科学] 登录...
( MIF ) has been demonstrated to mediate cardioprotection in ischemia/reperfusion injury and antagonize fibrotic effects through its receptor, CD 74, the function of the soluble CD 74 receptor ectodomain ( sCD 74) and its interaction with circulating MIF have not been explored in cardiac disease....
CXCL12/MIF-CXCR4 生物轴在治疗动脉粥样硬化 应用中的研究进展doi:10.20039/j.cnki.1007-3949.2024.09.012梁子舜蔡晶乔彤Chinese Journal of Arteriosclerosis
MIF inhibition with 4-IPP impaired in vitro NB aggressiveness, and improved drug response while delayed NB growth, improving survival of the NB xenograft model.Our findings suggest that BM infiltration by NB cells may be mediated, in part, by MIF-CXCR4 signaling. We demonstrate the antitumor ...
CXCL12/MIF-CXCR4生物轴在治疗动脉粥样硬化应用中的研究进展 动脉粥样硬化(As)是世界范围内死亡率和发病率高的主要原因之一.趋化因子及其受体参与As的发病机制.CXC趋化因子配体12(CXCL12)是趋化因子家族的成员,巨噬细胞迁移抑制... 梁子舜,蔡晶,乔彤 - 《中国动脉硬化杂志》 被引量: 0发表: 2024年 CXCL12(SDF-...
MIFNSCLCEpithelial mesenchymal crosstalkCancerOverexpression of C-X-C chemokine receptor type 4 (CXCR4) has been shown in several cancers, including nonsmall cell lung cancer (NSCLC) and is linked to early metastasis and worse prognosis. The crosstalk between cancer cells and tumor stroma promotes ...
The MIF/CXCR4 axis is the most common ligand-receptor interaction between macrophages and tumor cells. GIST cells can regulate macrophage M2 polarization through the MIF/CXCR4 axis.Shuo-meng XiaoRui XuYing-xin YangRui ZhaoYuan XieXu-dan Lei...
S35MIF-CXCR4 as a novel axis for mesenchymal stem cells recruitment to tumours in vivoMesenchymal Stem Cells (MSCs) are inherently tumour-homing, immunosuppressive and can be isolated, cultured, expanded, and transduced, making them viable candidates for cell therapy. MSCs can also be useful in ...