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Conclusion: Early hydrocortisone therapy (Ͻ 24 hours) did not shorten the length of iNO treatment, mechanical ventilation, or the duration of oxygen therapy for newborns with PPHN. Newborns with PPHN secondary to meconium aspiration syndrome more commonly developed inotrope resistant hypotension within...
Management included initial intubation with mechanical ventilation and resuscitation with blood transfusions and intravenous fluids. Medications used in therapy included Prednisolone (1–3mg/kg/day), intravenous immunoglobulin IVIG (1gram/kg/day x 5 days ) and cyclosporine A (2–10mg/kg/day) aiming...
Methods: A randomized, double- blind placebo-controlled study of iNO in 207 infants Ͻ34 weeks gestation who were undergoing mechanical ventilation for RDS. Infants were randomized to receive iNO (10 ppm on day 1, followed by 5 ppm for six additional days) or placebo for seven days. Data...