Maximum dose: 20 mg Parenteral: IM ADMINISTRATION: 0.1 to 0.15 mg/kg IM once, with some patients requiring doses of 0.5 mg/kgMaximum total dose: 10 mg IV ADMINISTRATION:6 months to 5 years:Initial dose: 0.05 to
Nasal Spray (5–20 mg/mL) 0.4–1.0 15 ∼ 60a Rectal Ampoule (1–5 mg/mL) 0.2-0.3 10-15 ∼ 50 a Bioavailability increases to 73% when administered in an aqueous cyclodextrin solution (17 mg/mL). Midazolam can be administered through intravenous (i.v.), intramuscular (i.m.), nas...
Anaphylactoid reaction: case report A 37-year-old man experienced an anaphylactoid reaction after receiving midazolam for anxiety. He was scheduled for surgical treatment of tennis elbow; IV midazolam 2mg was injected for anxiety. He developed pruritus, dyspnoea and chest tightness within 2minutes of...
Sedation in both adult and pediatric patients is reached within 3 to 5 minutes post intravenous (IV) injection. The time of onset is affected by the dose administered and the simultaneous administration of narcotic pre-medication. Seventy-one (71%) percent of the adult patients in clinical endos...
Water Solubility 54mg/L(24 ºC) BCS Class 1 LogP 2.73 CAS DataBase Reference 59467-70-8(CAS DataBase Reference) FDA UNII R60L0SM5BC ATC code N05CD08 NIST Chemistry Reference Midazolam(59467-70-8) UNSPSC Code 41116107 NACRES NA.24 Safety Symbol(GHS) Signal word Danger Hazard statem...
Midazolam IM, intranasal or buccal may be more effective and more rapid than Diazepam IV or rectal Lorazepam and Diazepam are preferred if available for other routes IV: 0.15 mg/kg up to 4 mg (then infused IV at 1 mcg/kg/min and titrated every 5 min as needed) up to 10 mg IM: 0.2...
Surgical sedation—0.5-1mg IV q2-3min prn; max 5mg General anesthesia induction—0.3mg/kg IV over 20-30sec Mechanical ventilation, sedation—0.02-0.1mg/kg/h IV prn • Contraindications—hypersensitivity to drug or class, glaucoma, shock, CNS depression ...
mg/kg intramuscular (IM) meperidine found that only 4 out of 6 pediatric patients who received 600 mcg/kg IV midazolam lost consciousness, with eye closing at 108 to 140 seconds. This group was compared with pediatric patients who were given thiopental 5 mg/kg IV; 6 out of 6 closed ...
Continuous IV infusion: Individualize infusion rate.Intranasal AdministrationAdminister intranasally using single-dose nasal spray unit supplied by manufacturer. Each nasal spray unit delivers 5 mg of midazolam in 0.1 mL of solution.Commercially available in boxes of 2 nasal spray units; each unit is...
In a placebo-controlled study, where saquinavir or placebo was administered orally as a 1200 mg dose three times a day for 5 days (n=12), a 56% reduction in the clearance of midazolam following a single 0.05 mg/kg IV dose was observed. The half-life was approximately doubled. ...