A 5-year-old boy developed agitation and a delusional reaction with hallucinations, after receiving midazolam as premedication prior to full-mouth dental rehabilitation. He was successfully treated with clonidin
Each dose was mixed with atropcne 0.02 mg·kg -1 plus an equal volume of cherry syrup and was given orally 20 to 30 min prior to surgery. A grade of 1 (asleep, difficult to arouse), 2 (asleep, easily aroused), 3 (awake, calm), 4 (awake, anxious, occasional cry), or 5 (...
Methods Eleven healthy subjects (8 men) received intravenous flumazenil (0.005 mg/kg) or placebo followed 7 minutes later by intravenous midazolam (0.025 mg/kg) in a randomized, double-blind crossover study. Plasma midazolam concentrations were obtained before dosing and at 5, 30, 60, 120, ...
03 mg/kg and fentanil 1 mug/kg, 1 minute before commencement of the procedure. During the port placement an anesthetist administered further bolus doses of 1 mg midazolam when the patient expressed discomfort. At patient-controlled group also patients were given the same drugs...
Midazolam (0.01-200 μmol/l) had a concentration-dependent maximal negative inotropic effect of 94 ± 4 % compared with the pre-drug value on the papillary muscles of animals pretreated with reserpin (RES) [7,5 mg/kg b.wt. i.p., 16-18 h prior to the study]. The IC25 and IC50 ...
MDZ 1′-hydroxylation rates varied from 0.025 to 3.106 nmol/min/mg protein, with significant correlation to CYP3A4 protein content ( r s = 0.92, P g; g.31611c>t) carriers had lower CYP3A5 protein content compared with noncarriers ( P = 0.004). No alternative splicing of CYP3A4 mRNA ...
The ambulances were stocked with blinded numbered syringes containing either 7 mg of midazolam or 20 mg of etomidate. No paralytics were used. If sedation was not achieved with the study drug, medics could request additional sedation from a medical command physician; only midazolam or diazepam ...
Anaesthesia induction was done with thiopental 7 mg kg-1 or midazolam 0.15 mg kg-1. After intubation with vecuronium 0.1 mg kg-1, general anaesthesia was maintained with isoflurane 1% and N2O/O2 (66%/33%). After full recovery from anaesthesia, pain scores were evaluated and intravenous ...
Methods Overweight (BMI for age ≥ 85th percentile) and obese (BMI for age ≥ 95th percentile) adolescents undergoing surgery received 2 or 3 mg intravenous midazolam as a sedative drug pre-operatively. Blood samples were collected until 6 or 8 h post-dose. Population pharma...
A prospective, randomized, trial was performed in children aged 1 months to 17 years with acute seizures lasting longer than 5 min. Children were randomly assigned to receive midazolam, 0.2 mg/kg, by the buccal, intranasal or intramuscular route. The primary endpoint was seizure cessation within...