In ischemic stroke, the progression of pathology involves changes in microvascular signaling whereby brain pericytes, perivascular cells wrapping the microcapillaries, are one of the early responders to the ischemic insult. Intercepting the pericyte signaling response peripherally by isolating pericyte-derived...
Cerebrovascular disease and depression symptoms in the cardiovascular health study. Stroke. 1999;30(10):2159-2166.PubMedGoogle ScholarCrossref 74. Tang WK, Chen YK, Lu JY, et al. White matter hyperintensities in post-stroke depression: a case control study. J Neurol Neurosurg Psychiatry. ...
Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study Article Open access 12 August 2020 FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease Article Open access 10 December 2020 MicroRNA...
Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndro...
Obesity represents a major risk factor for a plethora of severe diseases, including diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and cancer. It is often accompanied by an increased risk of mortality and, in the ca... I Savini,MV Catani,D Evangelista,... - 《Internation...
Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium BACKGROUND: Even in the absence of a previous myocardial infarction, patients with coronary artery disease often present with chronic regional wall motion ... JL...
Trial Registration ClinicalTrials.gov Identifier: NCT02257294 Introduction Ischemic heart disease is the leading cause of disability1 and death2 worldwide. Acute coronary thrombosis causes ST-elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (PCI) to emergently reopen the...
Diabetic retinopathy (DR) is a microvascular disease of the retina that affects almost all diabetic patients [1]. DR is characterized by symptoms such as blurred vision, floaters, and vision distortion, which can progress to partial or total vision loss in severe cases [2]. Current treatment ...
B. Oxidative stress and neurodegeneration in the ischemic overactive bladder. J. Urol. 178, 710–715 (2007). Article CAS PubMed Google Scholar Yamaguchi, O., Aikawa, K., Shishido, K. & Nomiya, M. Place of overactive bladder in male lower urinary tract symptoms. World J. Urol. 27,...
Abstract Microvascular dysfunction (MVD) contributes to several conditions that increase morbidity and mortality, including ischemic heart disease, heart failure, dementia, chronic kidney disease and hypertension. Consequently, MVD imposes a substantial burden on healthcare systems worldwide. In comparison to...