Raybin, D., Flavin, M.: Specific enzymatic tyrosilation of the α chain of tubulin and its possible roles in tubulin assembly and function. In: Cell Motility (eds.: R. Goldman, T. Pollard, J. Rosenbaum), pp. 1133–1138. Cold Spring Harbor Lab. 1976 Google Scholar Renaud, F. L., ...
If the surface lattice has an even number of these helices, then the microtubule has an overall helical structure. If the number is odd, the microtubule has a discontinuous helical surface lattice; it is said to have a seam because the subunits are mismatched between two protofilaments. ...
Microtubule proteins have been implicated in a variety of cellular functions such as intracellular translocation, lysosome function, cell motility, hormone release, and the lateral movement of proteins in plasma membranes. These have been reviewed in several monographs in recent years.45,61,187,217 ...
Overexpression and depletion studies indicate that WHAMM is important for maintaining Golgi structure and facilitating anterograde membrane transport. The ability of WHAMM to interact with microtubules plays a role in membrane tubulation, while its capacity to induce actin assembly promotes tubule ...
Microtubules in cardiomyocytes have been found to be closely related to the maintenance of normal structure and function of cardiomyocytes. The stability of microtubules is mainly regulated by microtubule-associated proteins(MAPs), including MAP2, MAP4 and tau. Post-translational modifications(PTMs) pla...
Toward understanding the structure and interactions of microtubules and motor proteins. PROTEINS: structure, function, and genetics 23:502–509.Wade, R.H., R. Horowitz, and R.A. Milligan. 1995. Toward understanding the structure and interactions of microtubules and motor proteins. Proteins. 23:...
However, non-kMTs have been observed in the vicinity of k-fibres and between sister kinetochores in metaphase6–8, which opens an interesting possibility that they may link sister k-fibres and balance the forces on kinetochores. Yet, the function of these non-kMTs is unknown. Here we show...
structure ofT. gondiicortical MT with (b) and without (c) TrxL2 at sites x and y. The structures show an asymmetric arrangement of the microtubule inner proteins (MIPs) including TrxL1 (gold or blue), TrxL2 (orange), and SPM1 (pink). An unoccupied site at the MT seam is labeled ...
cellular function. MT STRUCTURE MTs are hollow cylinders of approximately 24 nm in diameter that, in most eukaryotic cells, consist of 13 proto laments (Ledbetter and Porter, 1964). Each proto lament is composed of longitudi- nally stacked heterodimers of a- and b-tubulins (Figure 1). ...
The integration of specialized cell functions with cytoskeletal structure is a subject of active interest. Clearly, a correlation between the specialized function of muscle contractility and cytoskeletal elements such as microtubules, microfilaments, intermediate filaments, and the microtrabecular lattice shoul...