However, non-kMTs have been observed in the vicinity of k-fibres and between sister kinetochores in metaphase6–8, which opens an interesting possibility that they may link sister k-fibres and balance the forces on kinetochores. Yet, the function of these non-kMTs is unknown. Here we show...
Toward understanding the structure and interactions of microtubules and motor proteins. PROTEINS: structure, function, and genetics 23:502–509.Wade, R.H., R. Horowitz, and R.A. Milligan. 1995. Toward understanding the structure and interactions of microtubules and motor proteins. Proteins. 23:...
techniques can detect specific structures at an increased resolution, but the narrow spacing between neuronal microtubules poses challenges because most existing labelling strategies increase the effective microtubule diameter by 20–40 nm and will thereby blend neighbouring microtubules into one structure. He...
However, shortening loop L11 of KIF3C significantly increases the microtubule affinity of KIF3ACΔL11, revealing another structural and mechanistic property that can modulate processivity. The results presented provide new, to our knowledge, insights to understand structure-function relationships governing ...
Regarding the effect of MT-targeting agents on MT curvature, in vitro studies on the structure of Taxol-MT have demonstrated its impact on both individual protofilaments and the overall lattice of MT. Taxol straightens the protofilaments, while simultaneously enhancing heterogeneity and flexibility ...
McGill, M., Brinkley, B.R.: Human chromosomes and centrioles as nucleating sites for the in vitro assembly of microtubles from bovine brain tubulin. J. Cell Biol. 67, 189–199 (1975) McIntosh, J.R., Cande, W.Z., Snyder, J.A.: Structure and physiology of the mammalian mitotic...
1990: Role of preprophase band of microtubules on the spindle formation in allium cotyledon cells Cell Structure and Function 15(6): 476 Katsuta, J.; Shibaoka, H. 1992: Inhibition by kinase inhibitors of the development and the disappearance of the preprophase band of microtubules in tobacco ...
Recent evidence shows signaling, communication theoreticalmodels have predicted both classical quantuminformation processing paperwe show conduction pathways electronmobility possiblequantum tunneling superconductivityamong aromatic amino acids pathwayswithin tubulin match helical patterns microtubulelattice structure, ...
MTsametastableanddynamicnature.MTsadoptseveral distincthigher-orderorganizationsthatfunctionincelldivisionandcellmorphogenesis.Smallmolecularweightcompounds thatbindtubulinareusedasherbicidesandasresearchtoolstoinvestigateMTfunctionsinplantcells.Thedenovoformation ofMTsincellsrequiresconservedγ-tubulin-containingcomplexesand...
Along this hypotheti- cal process we can do effort to observe the continu- ous changes in the three-dimensional structure of the protein and modify the hypothetical process to make it more reliable. 2) Up to now MreB protein or MreB-related pro- tein has not been found in any cren...