MicroRNA--96 一、研究背景 宫颈癌是女性常见的恶性肿瘤之一,其发病率逐年上升。化疗是宫颈癌的一种常规治疗方法,但目前仍存在许多患者对化疗药物不敏感或耐药,影响治疗效果。因此,寻找能够预测化疗敏感性的生物标记物对于确定治疗方案和提高患者预后具有重要意义。 微小RNA(microRNA, miRNA)是一类长度约为22 nt的非...
目的:探讨MicroRNA-96(miR-96)对人视网膜色素上皮(RPE)细胞增殖和迁移的影响。 方法:实验研究。通过RNA原位杂交检测人胚胎眼(20周)石蜡切片中RPE层miR-96的表达情况。将miR-96和随机序列寡核苷酸链[阴性对照(NC)]通过阳离子脂质体介导...
Targaprimir-96 是microRNA-96 (miR-96)加工的有效抑制剂。Targaprimir-96 选择性地调节癌细胞中 miR-96 的产生并触发凋亡 (apoptosis)。Targaprimir-96 高亲和力的与 primary miR-96 (pri-miR-96) 结合。Targaprimir-96 直接与乳腺癌细胞中的 pri-miR-96 结合,并不影响健康乳腺细胞。
microRNA 96与语前非综合征型耳聋microRNA 96与语前非综合征型耳聋 作者:付四清 谌晖陈沛伟 陈观明 基本信息来源于合作网站,原文需代理用户跳转至来源网站获取 语前聋 突变 miR-96基因 摘要: 目的 探讨学语前非综合征型耳聋患儿miR-96基因突变频率及突变方式.方法 分别采集湖北地区125例非综合征型语前聋患儿及...
A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis influences Development of Pulmonary Hypertension et al. A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension. Am. J. Respir. Crit. Care Med. 191, ... E Wallace,NW Morre,XD Yang,... ...
Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (30 mg/kg) and subjected to 3 weeks of hypobaric hypoxia. In normoxia, rats were dosed with either a 5HT...
In addition, we found that the cysteine transporter excitatory amino acid carrier 1 (EAAC1), which is involved in neuronal GSH synthesis, is negatively regulated by the microRNA miR-96-5p, which exhibits a diurnal rhythm. Blocking miR-96-5p by intra- cerebroventricular administration of an ...
regulation of cell-cell adhesion in prostate cancer cells by microrna-96 系统标签: epcam carcinogenesis upregulation cadherin microrna prostate Carcinogenesis,2019,1–10doi:10.1093/carcin/bgz191dvsspuboNovmb18,2019172019;Revised:ob242019;Accepted:Novmb152019Thuho(s)2019.PubshdPss.OriginalArticleRegul...
The microRNA-183/182/96 cluster has been reported to be involved in tumorigenesis and progression in a variety of cancers, and it is a promising cancer prognostic biomarker. The goal of this study was to determine the expression levels of the miR-183/182/96 cluster in breast cancer tissues...
microRNA是一类在基因转录后过程中通过对靶mRNA的翻译抑制和降解,对基因表达起负调控作用的小的非编码RNA分子.细胞内脂类代谢除了受固醇调节元件结合蛋白(SREBP)与肝X受体α(LXRα)这两个典型的转录因子调控外,还受到多种miRNA的调控.miR-33是定位于SREBP基因内含子的miRNA,其通过抑制ABCA1和ABCG1的表达,从而调控...