Increased cellular levels of MicroRNA-9 and MicroRNA-221 correlate with Cancer stemness and predict poor outcome in human breast Cancer Cell. Physiol. Biochem., 48 (5) (2018), pp. 2205-2218 CrossrefView in ScopusGoogle Scholar [18] J.M. Gwak, H.J. Kim, E.J. Kim, Y.R. Chung, ...
结论电针曲池、足三里穴可促进室管膜下区神经干细胞增殖,其作用可能通过下调miR-9表达。%Objective To investigate the effect of electroacupuncture (EA) at Quchi (LI11) and Zusanli (ST36) acupoints on rats with fo-cal cerebral ischemia, and whether it was mediated by microRNA-9 (miR-9) ...
3 reagents referenced in The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome.
The functional significance of microRNA-9 (miR-9) during evolution is evidenced by its conservation at the nucleotide level from flies to humans but not its diverse expression patterns. Recent studies in several model systems reveal that miR-9 can regulate neurogenesis through its actions in neural...
Purpose The objective of the study was to investigate the role of microRNA-9 (miR-9) targeting forkhead box O1 (FOXO1) in the proliferation, migration, and invasion of breast cancer cells. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine the expressio...
dual luciferase reporter assay, Enzyme‐linkedimmunosorbent assay, and Hematoxylin‐Eosin staining assay were used to explorethe role of MCPIP1 and the interaction between MCPIP1, Sirtuin 1 (SIRT1), andmicroRNA‐9 (miR‐9). We found that the level of MCPIP1 increased and the level ofSIRT1...
MicroRNA-9调节Navl.1和Navl.2膜转运的分子机制研究 图1钠通道基本结构图【24】 Figure 1The basic structure of sodium channel Navl.1在胞体和树突上以及郎飞氏结节点部位表达,Navl.2在成年人的 中枢神经系统中大量表达,特别是在皮层和海马区,主要定位在无髓鞘的轴突 以及聚集在突触起始端,维持动作电位时程的...
MicroRNA-9 (miR-9), enriched in central nerve system (CNS) [28], contributes likely to multi-pathological processes including the neurogenesis [29], proliferation [30], migration and differentiation of neural progenitor cells [31], drug adaption [32], adult brain plasticity [33], neural cell...
目的探讨microRNA-9(miR-9)参与调控卵巢癌细胞EMT过程,以及影响卵巢癌细胞侵袭及转移的分子机制.方法使用TargetScan及PicTar数据库,预测可能靶向E-cadherin 3'UTR区的miRNA,双荧光素酶报告体系进行验证;上调候选miR后,用qRT-PCR和Western blot检测E-cadherin的表达变化;细胞免疫荧光观察E-cadherin,?-Catenin和Vimentin的...
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion Previous studies have demonstrated that the trafficking defects of Nav1.1/Nav1.2 are involved in the dementia pathophysiology. However, the detailed mechan.....