MicroRNA-21-5pMitogen-activated protein kinase kinase 3p38 mitogen-activated protein kinasekinaseTarget geneRegulation目的验证microRNA(miR)-21-5p与丝裂原活化蛋白激酶激酶3(MKK3)的靶向调控关系。方法构建MKK33'UTR报告载体(MKK3-3U)及突变载体(MKK3-3U-M);化学合成miR.21-5p模拟物(mimics)、miR-21-5p...
近日,来自河北医科大学第二医院李拥军课题组的研究人员发现,来自心力衰竭患者的心脏基质细胞来源的外泌体的再生修复作用发生障碍,这是由于外泌体中的microRNA-21-5p失调而导致的。该研究发表于Journal of clinical investigation(IF 13.125)杂志上。 一般认为,细胞疗法对受损的心肌再生具有潜在作用。基于细胞治疗的药物或...
(P<0.05).MicroRNA-21-5p对心肌再生的促进作用可能是通过抑制Pja2表达实现的,而Alx1虽受microRNA-21-5p的调控,但并不参与心脏再生过程.结论:在乳鼠心肌细胞增殖过程中,microRNA21-5p可调控Pja2的表达,并促进心肌细胞增殖水平;而直接敲低Pja2对心肌细胞再生也有明显促进作用,但对microRNA21-5p的表达没有明显...
miR-21-5p expression was enhanced while RUNX1 expression was reduced in the Ago-miR-21-5p group (bothP < 0.05). The expression trend of miR-21-5p was
Recently, these effects were found to be associated, at least in part, with a modulation of microRNA expression. However, the mechanisms by which single modulated microRNAs mediate the anticancer effects of metformin are not entirely clear and knowledge of such a process could be vital to ...
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for treating myocardial infarction have limited success. An effective approach may benefit from resolution of excessive inflammation combined with enhancement of angiogenesis. Here, we developed a microRNA-21-5p delivery...
Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis Author links open overlay panelXin Zhou a b 1, Xili Chu b 1, Hongtao Yuan b, Jie Qiu a b, Chuanliang Zhao a b, Danqing Xin b, Tingting Li b, Weiwei ...
In this study, we discovered that the regulation of the heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) in cervical cancer. RT-qPCR was conducted to detect the expression of HAND2-AS1 and microRNA-21-5p (miR-21-5p). The relationship of HAND2-AS1 and miR-21...
Metformin is a commonly prescribed type II diabetes medication that exhibits promising anticancer effects. Recently, these effects were found to be associated, at least in part, with a modulation of microRNA expression. However, the mechanisms by which s
Exosomal microRNA-21-5p from gastric cancer cells promotes angiogenesis by targeting LEMD3 in human endothelial cellsdoi:10.1515/oncologie-2024-0198exosomesgastric cancermiR-21-5pLEM domain containing 3 (LEMD3)proliferationThe effect of exosome-derived miR-21-5p from gastric cancer (GC) on ...