MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 SignalingView further author informationzhaohuili650@hotmail.comZhaohui LiView further author informationZi YeView further author informationTianju MaView further author information...
迷迭香酸可以使结直肠癌细胞中miR-1225-5p上调,防止结直肠癌细胞的迁移和侵袭;并降低N-cadherin的表达,增加E-cadherin的表达,使结直肠癌细胞侵袭与迁移相关基质金属蛋白酶1(matrix metalloproteinase 1,MMP1)、MMP3、MMP9被抑制[13]。Han等[14]研究发现,在胰腺癌细胞中迷迭香酸可呈剂量相关性显著提高miR-506的表达...
同时,众多研究团队对不同年龄段人群组织或血清中miRNA进行分析鉴定后发现:miR-29b、miR-106b、miR-130b、miR-142-5p、miR-340、miR-340-3p,miR-374a-5p、miR-376c、miR-151a-5p、miR-181a-5p和miR-1248随年龄增加表达显著下调,miR-92a、miR-222、miR-375...
然后,作者研究了10种miRNA在C57小鼠原代软骨细胞中5p和3p链表达的比例,结果表明,与其他miRNA不同的是,前体miRNA-455双链在软骨细胞中产生几乎相同比例的5P和3P链。并且作者通过qPCR技术检测发现miRNA-455-5p和3p链在人类关节软骨细胞的...
AR is a ligand-dependent transcription factor that regulates the expression of androgen target genes. Several miRNAs have been implicated in prostate cancer (CaP) development, including miR-125b [35], miR-21, miR-10a, miR-141, miR-150*, and miR-1225-5p [36,37], miR-205 and miR-200c...
miR-122-5p, miR-125b-5p, miR-24, let-7a, let-7d-5p) had multiple potential sites of interaction with the mt genome that included both coding and non coding areas (Table2). Non coding areas for interaction included the Hypervariable Region 1 (HVRI) for miR-23b and miR-122-5p; with...
(miR-1225-3p,miR-1234-3p,miR-1260b, andmiR-1470), relapse was more likely in the high score group than in the low score group. Conversely, for the two downregulated miRNAs (miR-6834-3pandmiR-6875-5p), relapse was more likely in the low score group than in the high score group. ...
hsa-miR-1224-5p, hsa-miR-1225-3p, hsa-miR-1225-5p, hsa-miR-1226*, hsa-miR-1227, hsa-miR-1228, hsa-miR-1229, hsa-miR-1234, hsa-miR-1237, hsa-miR-1238, hsa-miR-124, hsa-miR-129*, hsa-miR-129-3p, hsa-miR-136*, hsa-miR-187*, hsa-miR-188-5p, hsa-miR-190b, hsa-miR...
To disentangle the intracellular order of events that produce multiple miR-34-5p isoforms, we analyzed SLAMseq small RNA libraries (Figure 3E and F). In contrast to steady-state small RNAs, which displayed compound length profile across the entire metabolic labeling time course (black heatmap, ...
( *0p.0<5, 0*.0* 5p, *<* 0p.0<1)0,. 0w1)h,iwle hniloe sniognsiifgicnainfitc adnitffderifefnecrens cweserwe edretdecetteedct eind tinhe theexperxepsrseisosnio onf omf miRi‐R1-214234, 3m, miRiR‐1-213283,8 ,mmiRiR‐5...