Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer's disease and its mouse models, induced expression of Axl and Mer in amyloid plaque鈥揳ssociated ...
et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol 22, 586–594 (2021). https://doi.org/10.1038/s41590-021-00913-5 Download citation Received05 May 2020 Accepted05 March 2021 Published15 April 2021 Issue DateMay 2021 DOIhttps://doi.org/10.1038/s41590...
Microglia use TAM receptors to detect and engulf amyloid beta plaques Nat. Immunol., 22 (2021), pp. 586-594, 10.1038/s41590-021-00913-5 View in ScopusGoogle Scholar 191 A.P. Robinson, T.M. White, D.W. Mason Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies...
astrocytes suggests they may have limited ability to respond directly to various pathogens. Instead, they rely on microglia to detect pathogens and communicate with astrocytes to induce their activation. Specifically, in the case of TLR4 activation triggered by LPS, microglia are directly involved in ...
To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
and which of these responses are beneficial or detrimental in AD. Initial studies of microglial function in AD models have been focused on phagocytosis and release of pro-inflammatory mediators. Aβ has been postulated to directly activate CD36 signaling and other membrane receptors, such as toll ...
Interestingly, these results are comparable to those obtained in primary microglia of NRF2-deficient mice [20], [23], indicating a crosstalk between CX3CR1/NRF2/TAM receptors and also its implication in phagocytosis. It has been shown that Gas6-Axl signalling plays an important role in ...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
and therefore should be kept in mind when designing such experiments. In addition to the activation state, ECM components may also affect microglial adhesion, migration, and morphology, as in the case of cell-matrix signaling mediated by transmembrane ECM receptors known as integrins [134,135,136...
(GAS6), and Protein S are the second group of stimuli for activating dendritic cells including microglia and macrophages that possess PS receptors and TAM (Tyrosine-Protein Kinase Receptor TYRO3/AXL Receptor Tyrosine Kinase/Tyrosine-Protein Kinase Receptor Mer) receptors6. Intercellular Adhesion ...