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Microglia, seen from the CX3CR1 angle. Front Cell Neurosci. 2013;7:26. 21. Tay TL, Sagar, Dautzenberg J, Grun D, Prinz M. Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration. Acta Neuropathol Commun. 2018;6:87. 22. Matcovitch-Natan O, Winter ...
Microglia, seen from the CX3CR1 angle. Front Cell Neurosci. 2013;7:26. Article PubMed PubMed Central CAS Google Scholar Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, et al. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of ...
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Jung Microglia, seen from the CX3CR1 angle Front. Cell. Neurosci., 7 (2013), p. 26 Google Scholar Yona et al., 2013 S. Yona, K.W. Kim, Y. Wolf, A. Mildner, D. Varol, M. Breker, D. Strauss-Ayali, S. Viukov, M. Guilliams, A. Misharin, D.A. Hume, H. Perlman, B...
1). However, subretinal changes were also different from that seen in mice with spots coalesced into a more reticular pattern and not covering the whole retina but located in the far and mid-peripheral retina. Additionally, the spots did not autofluoresce. These studies highlighted a possible ...
Tissue microarchitecture and mechanics are important in development and pathologies of the Central Nervous System (CNS); however, their coordinating mechanisms are unclear. Here, we report that during colonization of the retina, microglia contacts the de
To investigate the molecular mechanisms through which microglia and CNS-infiltrating myeloid cells cooperate to sustain CNS inflammation, we used ex vivo single-cell RNA-sequencing (scRNA-seq) and liquid chromatography–mass spectrometry (LC–MS)-based analyses ofCx3cr1-YFPcreERT2R26tdTomatofate-mapp...
Strikingly, acute ROCK2 inhibition with KD025 under repopulating microglia conditions abolished these neuroprotective effects, with the hippocampal tissue volumes in these mice becoming indistinguishable from those seen in the TBI control mice (i.e., those with resident microglia; Fig. 4M). These ...
In 2005, microglial extreme dynamism in the intact brain was examined for the first time, through the skull of CX3CR1-GFP mice in which microglia are fluorescently labeled.55,56 As a result, microglia are now considered to be the most dynamic cells of the healthy mature brain.151 This ...