factors (e.g., RORγt)24,25,26,27and acquire gut-specific phenotypes and metabolic patterns to maintain intestinal homeostasis28,29,30. The mechanisms by which the microbiome regulates intestinal Treg homeostasis have not been fully elucidated. In this study, we showed that the differentiation of...
Biagi, E. et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLOS ONE 5, e10667 (2010). Article PubMed PubMed Central CAS Google Scholar Leclercq, S. et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcoho...
Our evolving understanding of intestinal microbiota-derived physiological modulators (e.g., short-chain fatty acids) and pathogenic mediators (e.g., trimethylamine N-oxide) of host disease susceptibility have created novel potential therapeutic opportunities for improved cardiovascular health. This review ...
transplantation obviously mitigated CRS-induced intestinal epithelial impairment (Fig. 11A–D). Fig. 11 Ri. treatment reversed colon barrier impairment in CRS mice. A, B H&E staining of the mice colons (scale bar 50 μm) along with the histological score analysis. C, D IF images C and M...
the IM metabolized the monomeric and dimeric flavanols to products that are absorbed from the intestinal tract. These metabolites were 5-(3,4-dihydroxyphenyl)-valerolactone (DHPV) and 4-hydroxy-5-(3,4-dihydroxyphenyl)-valeric acid (4H-DHPVA).E. lentahas been shown in vitro to perform the...
Compliquant cette interaction, les traitements contre le cancer altèrent l’équilibre entre épithélium, microbiote et immunité intestinale, dictant ainsi la réponse clinique. Ce séminaire se concentre sur l’impact de la composition du microbiote intestinal sur les propriétés thérapeutiques ...
The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we investigated the contribution of the intestinal microbiome on treatment outcomes in a heterogeneous cohort that included multiple cancer types to identify microbes
infantis through resolving Fuc, revealing a trophic interaction between E. hallii and B. infantis [141]. Apart from the capability of HMOs to modulate the composition of Bifidobacteria in the intestinal tract, they can directly interact with other bacteria and affect the distribution of gut ...
Petrof, E. O. et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut Microbiome 1, 3 (2013). Article PubMed PubMed Central Google Scholar Lawley, T. D. et al. Targeted restoration of the intestinal microbiota with a simple...
we colonized pregnant GF mice at E15 with the human microbiome of interest, and the newborn pups were not separated from the colonized mother until weaning thus the offspring acquired a microbiota reflecting the human microbiome of interest from contact with the mother15. The fecal samples were ...