(or plate) assay and the turbidimetric (or tube) assay. Table 1 lists all the antibiotics that contain microbial assays and specifies the type of assay (cylinder-plate or turbidimetric). Table 1 Antibiotic Type of Assay Amphotericin B Cylinder-plate Bacitracin Cylinder-plate Bleomycin Cylinder-...
antibioticsassaysmicrobial抗生素antibioticassay á81ñANTIBIOTICS—MICROBIALASSAYSINTRODUCTIONANDGENERALINFORMATIONTheactivity(potency)ofantibioticscanbedemonstratedbytheirinhibitoryeffectonmicroorganismsundersuitablecondi-tions.Areductioninantimicrobialactivitymaynotbeadequatelydemonstratedbychemicalmethods.Thischaptersummari-zes...
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of the standard across all plates. came possible. such antibiotics had an activity equivalent to turbidimetric assay:to avoid systematic bias, place a given number of mg of the original reference standard. in replicate tubes randomly in separate racks so that each rack most instances, however, ...
(2009) 62, 5–16 & 2009 Japan Antibiotics Research Association All rights reserved 0021-8820/09 $32.00 www.nature.com/ja Microbial drug discovery: 80 years of progress Arnold L Demain1 and Sergio Sanchez2 Microbes have made a phenomenal contribution to the health and well-being of people ...
Microbes have made a phenomenal contribution to the health and well-being of people throughout the world. In addition to producing many primary metabolites, such as amino acids, vitamins and nucleotides, they are capable of making secondary metabolites,
Antimicrobial activity of the compounds was tested by Kirby-Bauer/disk diffusion assay [32], by applying 10 μg of the inhibitory compounds to 6 mm filter paper discs at concentration ranging from 10000 to 0.05 μg/ml in 10-fold stepwise dilutions. As for (R)-6-fluoromevalonate diphosphate...
The regulation of the intestinal microbiota by ILA was microbiota-dependent and specifically increasing indoles levels under conditions of dybiosis induced by Citrobacter rodentium or DSS, but not of microbiota disruption with antibiotics. The anti-inflammatory and intestinal barrier-strengthening effects of...
MICRO-FRACTIONATION FOR ACTIVE PEAK IDENTIFICATION Active peaks cannot be identified merely by looking at the data of LC- UV-MS or LC-UV. Ways of detecting biological activity using on-line systems that directly connect to HPLC have been reported pre- viously,40,41 but the range of assay ...
During the fermentation, antibiotic production can be followed by testing samples of the broth and/or of the extracts of the mycelial mass for antibiotic activity. Organisms known to be sensitive to M 9026 antibiotics are useful for this purpose. An especially useful assay organism is the Staphylo...