Norbert Arnold1 and Ludger A Wessjohann1 The reliable assessment of the biological activity of a minor component embedded in a complex matrix of several hundred compounds is a difficult but common task in the search for natural product-based antibiotics, for example, by bioassay-guided fractionation...
For example, vancomycin is found to be an integral part of many antibiotics: actinoidin A, complestatin, balhimyicn etc. Gossypol, a natural biaryl pigment found in cottonseed, has shown male antifertility activity. Among liganans, steganacin is a constituent of Steganotaenia araliacea ...
This invention was made with government support under Grant Number CA174401 awarded by the National Institutes of Health. The government has certain rights in the invention. BACKGROUND The rapid emergence of antibiotic resistance, and decline in discovery of new antibiotics, has created a significant...
Ertapenem sodium (ERTM) is a synthetic antimicrobial agent of the class of carbapenems that have action against Gram-negative, Gram-positive, aerobic and anaerobic microorganisms. The lack of new effective antibiotics against multidrug-resistant pathogens is a constant concern. The...
highly sensitive, direct-from-patient, microfluidic droplet-based bioassay platform that offers single cell based analysis for efficient monitoring of bacterial infection and cell function, as well as for high throughput testing of the susceptibility of single cells to antibiotics and other pharmaceutical...
molecules Article Bioassay-Guided Isolation of Anti-Inflammatory Components from the Bulbs of Lilium brownii var. viridulum and Identifying the Underlying Mechanism through Acting on the NF-κB/MAPKs Pathway Ting Ma †, Zhen Wang †, Yang-Mei Zhang, Jian-Guang Luo * and Ling-Yi Kong * ...
Separation of antibiotics by counter-current chromatography. J. Chromatogr. 1998, 812, 35–52. 102. Foucault, A.P.; Chevolot, L. Counter-current chromatography: Instrumentation, solvent selection and some recent applications to natural product purification. J. Chromatogr. 1998, 808, 3–22. 103...