我的主要工作是做手性合成的,其中一个主要的反应就是MA reaction,我希望shhx2006能给出一些综述文章就更好了。 其中“CuBr2催化下的 Michael addition 反应”是我用到的,我用的catalyst: CuBr2.DMS ,yields more than 70%,出于对有机化学的论坛的尊重,该催化剂的配置见:http://bbs.organicchem.com/dispb ....
CCHNuECCHNu +E 反应实例 H3C 1)KCN C CH NO2 2)H H3C CH3H2 H3CCCNO2 CNC Michael反应 •定义：碳负离子对于缺电子的碳碳双键的加成反应 称为Michael反应，又叫Michael加成。其中双键碳原子与吸电子基（如羧基）直接相连构成共轭体系。反应式：Michael反应机理 Michael反应 •1.负碳离子与,-不饱和醛(...
Due to its high potential for the formation of carbon-carbon bonds, Michael addition reaction is one of the closest reactions to the heart of synthetic organic chemists. Electrochemistry presents a very stimulating and divergent resource for selective oxidation and reduction in organic chemistry, ...
The key attribute of the thiol-Michael addition reaction that makes it a prized tool in materials science is its modular “click” nature, which allows for the implementation of this highly efficient, “green” reaction in applications that vary from small molecule synthesis to in situ polymer mo...
1)Michael addition reaction迈克尔加成反应 1.2-cyanoethyl-5-norbornene-2-carboxaldehyde was synthesized through a Michael addition reaction of acrylonitrile and 5-norbornene-2-carboxaldehyde using tert-butyl alcohol and potassium hydroxide as catalyst at room temperature.此中间体由丙烯腈与5-降冰片稀-2-醛...
Lewis acid, Me 3 SiOTf, has been shown to be a promising promoter for aza-Michael reaction of relatively acidic primary amide with α,β-unsaturated ketone. A sries of α,β-unsaturated ketones was transformed to their corresponding β-amido ketones with moderate yields under this reaction cond...
1)asymmetric Michael addition reaction不对称Michael加成反应 1.The optically pure compounds (5R,4R)-5-(l-menthyloxy)-4-dialkyloxyphosphonyl-butyrolactones were obtained by using asymmetric Michael addition reaction of 5(R)-5(l-menthyloxy)-2(5H)-furanone with nucleophilic trialkylphosphite.手性呋...
s,cinchonaalkaloidsI-IVandaminethioureasV-VIcatalystIIhasthemostfavorablecharacteristicsintermsofreactiontime(3h)andenantioselectivity(53%ee)hydroxylgroupsEffectofSolventontheCatalyticAsymmetricMichaelAdditionReactionof1H-Benzo[d][1,2,3]triazole(1a)andtrans-β-Nitrostyrene(2a)CatalystIIPromotedMichaelAddition...
In these cases the Michael adducts can even be prepared in a three-component reaction. A mechanism, with as first step the oxidative addition of 2ad to Pd0, is proposed.关键词: Michael addition Palladium C-H activation DOI: 10.1002/ejoc.201000961 ...
addition n. 1.[U]加;加法 2.[C]增加物;添加物 3.[U]增加;添加 reaction n.[U,C] 1.反应,回应 2.(对旧观念等的)抗拒 3.生理反应,副作用 4.反应能力(通常用复数) 5.反对,反动,阻碍 6.化学反应 7.反作用力 cis addition 【建】 顺(式)加(成)作用 addition compound 【医】 加成产物 ...