MiaPaCa-2 胰腺癌细胞含有 Kras G12C 突变,为新药研究中Kras 靶点相关研究热门模型。发布于 2025-02-14 11:41・IP 属地江苏 肿瘤 药理药效 模型 赞同添加评论 分享喜欢收藏申请转载 写下你的评论... 还没有评论,发表第一个评论吧 推荐阅读 m6A研究的路子有多野?明年国自然...
欢迎前来上海雅吉生物科技有限公司-稳转细胞系类产品,选购MIAPaCa2-KRAS-G12D-HiBiT-1B4,想了解更多MIAPaCa2-KRAS-G12D-HiBiT-1B4,请进入稳转细胞系商品任你选购
MIA PaCa-2细胞系来源于一名65岁男性胰腺癌组织,是肿瘤研究领域不可或缺的资产。其被广泛用于胰腺导管腺癌(PDAC)的研究,这是一种众所周知的侵袭性和致死性癌症类型。该细胞系提供了反映PDAC细胞特征的实体瘤模型。该细胞系的关键属性之一是其遗传谱,其中包括KRAS和TP53等关键基因的突变,这些基因是胰腺癌患者观察到...
Both cell lines have KRAS and TP53 mutations and homozygous deletions including the first 3 exons of CDKN2A/p16(INK4A), but no SMAD4/DPC4 mutations or microsatellite instability. Both have neuroendocrine differentiation and SSTR2 receptors, precisely the features making them suitable for the ...
三是传代的时候切记不可消化太久，消化过久细胞破碎释放出DNA也会使细胞粘连，消化到细胞变圆或者可以拍...
the MiaPaCa-2 pancreatic cancer cell line is widely used to study pancreatic ductal adenocarcinoma progression17because of several key factors: first of all it is KRAS mutant18, making it an ideal target for anticancer drugs to develop proper therapeutic strategies;19,20secondly, even if they are...
9. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer[J].Kim; Jimi;McMillan; Elizabeth;Kim; Hyun Seok;Venkateswaran; Niranjan;Makkar; Gurbani;Rodriguez-Canales; Jaime;Villalobos; Pamela;Neggers; Jasper Edgar;Mendiratta; Saurabh;Wei; Shuguang;Landesman; Y...
MIAPaCa2-KRAS-G12D-HiBiT-1B2产品价格:￥电议 产品编号:YW-0813 产品类别:稳转细胞系 生长特性:贴壁生长 培养体系:专用培养基 细胞形态:上皮细胞样订购热线:021-34661276 收藏此商品 我要询价 上海细胞库人源细胞系 稳转细胞系 基因敲除株 基因点突变细胞株 大鼠细胞系 小鼠细胞系 其他细胞系...
Both cell lines have KRAS and TP53 mutations and homozygous deletions including the first 3 exons of CDKN2A/ p16INK4A, but no SMAD4/DPC4 mutations or microsatellite instability. Both have neuroendocrine differentiation and SSTR2 receptors, precisely the features making them suitable for the ...
Genotyping of MIA PaCa-2 (Fig. 5A) and PANC-1 (Fig. 6A) confirmed the presence of a homozygous (p.G12C; GGT > TGT) and a heterozygous missense mutation (p.G12D; GGT > GAT) in codon 12 of KRAS respec- tively. This is a hotspot codon well known for ...