RAS(KRAS、HRAS和NRAS)突变驱动的癌症占人类癌症的 30%,尤其是非小细胞肺癌、结直肠癌和胰腺导管腺癌(PADC)。KRAS在PDAC突变中极其常见(92%),其次是结直肠癌(49%)和 NSCLC(29%)… 爱诺美康出国看病 国自然热点 | m6A修饰在基因表达调控中的作用机制 武汉瑞兴生物 急性胰腺炎(AP)小鼠模型的建模方法 原型物种:...
MIAPaCa2-KRAS-G12D-HiBiT-1B2产品价格:￥电议 产品编号:YW-0813 产品类别:稳转细胞系 生长特性:贴壁生长 培养体系:专用培养基 细胞形态:上皮细胞样订购热线:021-34661276 收藏此商品 我要询价 上海细胞库人源细胞系 稳转细胞系 基因敲除株 基因点突变细胞株 大鼠细胞系 小鼠细胞系 其他细胞系...
MIA PaCa-2细胞系来源于一名65岁男性胰腺癌组织,是肿瘤研究领域不可或缺的资产。其被广泛用于胰腺导管腺癌(PDAC)的研究,这是一种众所周知的侵袭性和致死性癌症类型。该细胞系提供了反映PDAC细胞特征的实体瘤模型。该细胞系的关键属性之一是其遗传谱,其中包括KRAS和TP53等关键基因的突变,这些基因是胰腺癌患者观察到...
Both cell lines have KRAS and TP53 mutations and homozygous deletions including the first 3 exons of CDKN2A/ p16INK4A, but no SMAD4/DPC4 mutations or microsatellite instability. Both have neuroendocrine differentiation and SSTR2 receptors, precisely the features making them suitable for the ...
细胞系名称:R26-CAG-LSL-Kras*G12C-IRES-Luc(BABL/c) 目录号:NM-YD15 R26-CAG-loxp-tdTomato-loxp2272-Tag-IRES-EGFP-2A-Luc-loxp-loxp2272/Alb-Cre-Tg 细胞系名称:R26-CAG-loxp-tdTomato-loxp2272-Tag-IRES-EGFP-2A-Luc-loxp-loxp2272/Alb-Cre-Tg 目录号:NM-YD14 Smad4-Flox/Kras-LSL-G12D/...
the MiaPaCa-2 pancreatic cancer cell line is widely used to study pancreatic ductal adenocarcinoma progression17because of several key factors: first of all it is KRAS mutant18, making it an ideal target for anticancer drugs to develop proper therapeutic strategies;19,20secondly, even if they are...
9. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer[J].Kim; Jimi;McMillan; Elizabeth;Kim; Hyun Seok;Venkateswaran; Niranjan;Makkar; Gurbani;Rodriguez-Canales; Jaime;Villalobos; Pamela;Neggers; Jasper Edgar;Mendiratta; Saurabh;Wei; Shuguang;Landesman; Y...
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Both cell lines have KRAS and TP53 mutations and homozygous deletions including the first 3 exons of CDKN2A/p16(INK4A), but no SMAD4/DPC4 mutations or microsatellite instability. Both have neuroendocrine differentiation and SSTR2 receptors, precisely the features making them suitable for the ...
Genotyping of MIA PaCa-2 (Fig. 5A) and PANC-1 (Fig. 6A) confirmed the presence of a homozygous (p.G12C; GGT > TGT) and a heterozygous missense mutation (p.G12D; GGT > GAT) in codon 12 of KRAS respec- tively. This is a hotspot codon well known for ...