Huntington's disease (HD) cellular pathology is characterised by the aggregation of mutant huntingtin (mHTT) protein into inclusion bodies. The present paper compared the sensitivity of five widely used mHTT antibodies (S830; MW8; EM48; 1C2; ubiquitin) against mice from five commonly used HD ...
Among them, Huntington's disease (HD) is caused by an expanded polyglutamine repeat stretch in the N terminus of the mutant huntingtin protein (mHTT), which gets cleaved and aggregates in the brain. Recently established human induced pluripotent stem cell-derived HD neurons exhibit some disease-...
生物活性 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) ...
Biochemical investigations of mouse brain homogenates revealed high HSA predominantly in protein fractions that contain small mHTT fibrils, suggesting that such structures are responsible for this activity in vivo. Finally, using an inducible Drosophila model of HD, we demonstrated that the formation of...
LC3-mHTT-IN-AN1 价格: ￥3304/支 产品详情:LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT)... 纯度:98% 包装规格:5 mg 用途:科学研究、研发 货号:C110254 品牌:ChemeGen 产地:上海 LC3-mHTT-IN-AN2相关供应商报价...
For our genome-wide CNS screening, we employed two well-characterized, high-titer vesicular stomatitis virus G protein (VSV-G)-pseudotyped lentiviral genome-wide murine pooled libraries: one for shRNA, RNAi-based screening and one for single-guide RNA (sgRNA) CRISPR-based screening (Doench et...
Among them, Huntington's disease (HD) is caused by an expanded polyglutamine repeat stretch in the N terminus of the mutant huntingtin protein (mHTT), which gets cleaved and aggregates in the brain. Recently established human induced pluripotent stem cell-derived HD neurons exhibit some disease-...
mHtt gene-dose impacts on DARPP32 protein levels.Douglas YoungFranziska MayerNella VidottoTatjana SchweizerRamon BerthDorothee AbramowskiDerya R. ShimshekP. Herman Van der PuttenPeter Schmid
Background Proteolytic cleavage of the mutant huntingtin protein (mHtt) leads to toxic N-terminal mHtt fragments, which are known to disrupt mitochondrial function. Olesoxime, a small cholesterol-like molecule, targets mitochondria and has demonstrated therapeutic efficacy in a variety of disease ...
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease...