其他LAG-3靶向药物也被用于癌症治疗。IMP321是一种可溶性重组融合蛋白,由LAG-3的胞外区和IgG的Fc区组成,通过MHCII介导反向信号激活抗原提呈细胞,导致IL-12和TNF的增加,CD80和CD86的上调。在目前进行的临床试验中,IMP321单药治疗或与其他疗法联合治疗的疗效一般。通过MHCII反向信号的细节仍然未知,需要仔细研究。 抗-...
百度试题 结果1 题目提供B细胞活化的共刺激信号 A. CD21 B. CD40 C. CD22 D. MHCII E. CD86 相关知识点: 试题来源: 解析 B 反馈 收藏
DCs in the form of immunological synapses, naïve Th cells are activated and expanded by two signals from the same DC: one from αβ TCR/CD4 engagement with antigenic peptide in the context of MHCII and the other one through CD28 engagement by CD80 and/or CD86 (Fig. 4a) [34, 48]....
Thus, the MHCII-, CD80-, CD86-initiated production of IL-4 and IL-2 from ILC2s and T cells coordinates efficient T cell and ILC2 proliferation and type-2 cytokine expression. Human ILC2s Express MHCII and Present Antigen to T Cells In parallel studies, we assessed MHCII expression on ...
TLR2 is essential for OmpA-induced nuclear translocation of NF-κB, activation of ERK and expression of MHCII and CD86 on B cells.Rajsekhar, BhowmickDebasis, PoreManoj, K. Chakrabarti
These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do not express pan markers of myeloid DCs (CD11c), plasmacytoid DCs (Ly6C), or macrophages (F4/80), and their frequency is inversely correlated with myeloid‐derived suppressor cells (MDSCs) ...
(P5). P5 and P6 sub-populations were also characterized for the expression of CD24, CD40 and CD86 co-stimulatory molecules as well CD11b (Fig.3a, bottom panels). P5, P6 and P7 cells were also analyzed via light microscopy (Fig.3b). Between P5 and P6 sub-populations, P5 showed higher...
MHCII+/−B cells exhibit a haploinsufficiency that reduces MHCII expression by half, on naïve, mature follicular (MF; B220+CD93−IgD+CD138−CD38hiGL-7−) and GC B cells (B220+CD38lowGL7+CD95+), including GC B cells in the LZ (CXCR4lowCD86hi) and DZ (CXCR4hiCD86low) ...
百度试题 题目成熟树突状细胞高表达的膜分子是()。 A.可高表达MHCII类分子B.可高表达MHCI类分子C.可高表达FcgR分子D.可高表达CD40/CD54分子E.可高表达CD80/CD86分子相关知识点: 试题来源: 解析 ACDE 反馈 收藏
These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do not express pan markers of myeloid DCs (CD11c), plasmacytoid DCs (Ly6C), or macrophages (F4/80), and their frequency is inversely correlated with myeloid‐derived suppressor cells (MDSCs) ...