(2016). MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNgamma- independent fashion and during development. Sci. Rep. 6, 24251.Vagaska, B., New, S. E., Alvarez-Gonzalez, C., D'Acquisto, F., Gomez, S. G., Bulstrode, N. W., and ...
25、the steroid and interferon gamma response pathways J. Mol Endocrinol, 2003, 17(12): 2509-2518.5 Zika E, Fauquier L, Vandel L, et al. Interplay among coactivatorassociated arginine methyltransferase 1, CBP, and CIITA in IFNgammainducible MHCII gene expressionJ. Proc Natl Acad Sci USA, 20...
Keywords:Hydrobiology;microRNA;interferon-gamma;MHCII;immuneresponse;Tetraodon nigroviridis 0引言35 IFN-γ是一种多能的细胞因子,作为宿主受感染前期分泌的“危险”信号分子,能快速 警告邻近的细胞,参与先天性和获得性免疫反应的起始阶段 [1] 。二聚化的IFN-γ与其特异受 ...
36,37,38,39,40. Analysis of the IFNγ gene (IFNG) mRNA levels revealed that it was expressed at significantly higher levels in EBVaGCs compared to other GC subtypes or normal control tissues (Fig.
MHCII类反式激活蛋白调控肿瘤细胞HLA分子的表达
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(hdLECs) with IFNγ, VEGF-C, IL-2, or TNF-α and found that IFNγ significantly increased expression of HLA-DRA and PD-L1 compared to no treatment, VEGF-C, IL-2 or TNF-α treatments (Figure 3A–D). These results were confirmed with flow cytometry (Figure 3E,F). IFNγ treatment ...
IFNgamma-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J. Exp. Med. 2018, 215, 3057–3074. [Google Scholar] [CrossRef] Cohen, J.N.; Tewalt, E.F.; Rouhani, S.; Buonomo, E.L.; Bruce, A.N.; Xu, X.; Bekiranov, S.; Fu, Y.-X....
MHC II is constitutively expressed in certain types of APCs (e.g., dendritic cells), but can be induced in other APCs (e.g., macrophages) by the pro-inflammatory cytokine interferon gamma (IFN-γ) at the tran- scriptional level8. MHC II transactivation by IFN-γrelies on the ...