von Bonin A, Martin S, Plaga S, Hebbelmann S, Weltzien HU: Puri(R)ed MHC class I molecules present hapten-conjugated peptides to TNP/H-2Kb-speci(R)c T-cell hybridomas. Immunol Lett 35:63±68, 1993von Bonin, A., Martin, S., Plaga, S., Hebbelmann, S., and Weltzien, H. ...
The present disclosure relates to MHC class I molecules, such as HLA-E, and peptide- MHC class I complexes with improved stability and/or refolding yield due to one or more introduced disulphide bridges. The disclosure further provides MHC class I multimers, cells, such as stem cells, comprisi...
Classical MHC I molecules present antigenic peptide ligands on infected cells to CD81 T cells, whereas a key function for non-classical MHC I molecules is to mediate inhibitory or activating stimuli in natural killer (NK) cells. The structural diversity of MHC I puts immense pressure on ...
DRiP, proteasome, antigen presentation, MHC class IMHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8+ T cells and the elimination of virally infected and cancerous cells. It has been argued that the dominant source of MHC class I-...
A Garcia-Lora,I Algarra,F Garrido - 《Journal of Cellular Physiology》 被引量: 386发表: 2010年 Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide... States that major histocompatibility complex (MHC) class I molecules present peptides derived from the en...
are extremely polymorphic. They are the main molecules that present pathogen-derived peptides to T cells, and they also interact with natural killer (NK)-cell receptors. By contrast, non-classical MHC class I molecules (also known as MHC class Ib molecules) are diverse in function and genetic...
Major histocompatibility complex (MHC) class I molecules display tens of thousands of peptides on the cell surface, derived from virtually all endogenous proteins, for inspection by cytotoxic T cells (CTLs). We show that, in normal mouse cells, MHC I molecules present a peptide encoded in the...
区分自我和非我是获得性免疫的重要过程,而抗原呈递能够帮助免疫系统识别细胞为自体健康细胞还是异常细胞。MHC复合物在这个过程中又起到了重要的作用,因此了解MHC I与MHC II在获得性免疫的学习中十分重要。本文主要根据2016年Kenneth等编写的Present Yourself! By MHC Class I and MHC Class II Molecules翻译而成 ...
MHC I-restricted NKT-like T cells (Fig.1a). Normally, murine thymocytes at the DP stage of their development do not express classical MHC I or MHC II molecules19. In search of a suitable approach to drive stable MHC I expression in DP, we selected the transcription factor Nlrc5 (also ...
Thus, four class I molecules with multiple amino acid differences in their alpha 1 and alpha 2 domains share a crossreactive epitope readily recognized by alloreactive CTL.(ABSTRACT TRUNCATED AT 250 WORDS) 展开 DOI: 10.1084/jem.168.1.307 被引量: 35 ...