von Bonin A, Martin S, Plaga S, Hebbelmann S, Weltzien HU: Puri(R)ed MHC class I molecules present hapten-conjugated peptides to TNP/H-2Kb-speci(R)c T-cell hybridomas. Immunol Lett 35:63±68, 1993von Bonin, A., Martin, S., Plaga, S., Hebbelmann, S., and Welt- zien, H...
DRiP, proteasome, antigen presentation, MHC class IMHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8+ T cells and the elimination of virally infected and cancerous cells. It has been argued that the dominant source of MHC class I-...
Classical MHC I molecules present antigenic peptide ligands on infected cells to CD81 T cells, whereas a key function for non-classical MHC I molecules is to mediate inhibitory or activating stimuli in natural killer (NK) cells. The structural diversity of MHC I puts immense pressure on ...
Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide... States that major histocompatibility complex (MHC) class I molecules present peptides derived from the endogenous protein pool to cytotoxic T lymphocytes, ... Spies,T.,Cerundolo,... - 《Nature》 被引...
Immune molecules have been discovered recently to play critical roles in the development, function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed in the central nervous system and regulate activity-dependent refinement of visual projections during late postnatal devel...
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with the signal to detect and eliminate the infected or cancerous cells. In the context of cancer, owing to the crucial immune-regulatory roles played...
are extremely polymorphic. They are the main molecules that present pathogen-derived peptides to T cells, and they also interact with natural killer (NK)-cell receptors. By contrast, non-classical MHC class I molecules (also known as MHC class Ib molecules) are diverse in function and genetic...
MHC复合物在这个过程中又起到了重要的作用,因此了解MHC I与MHC II在获得性免疫的学习中十分重要。本文主要根据2016年Kenneth等编写的Present Yourself! By MHC Class I and MHC Class II Molecules翻译而成 天然免疫系统主要依赖模式识别受体发现病原体相关分子模式和损伤相关分子模式感知组织稳态的变化,快速做出相应...
Major histocompatibility complex class I (MHC I) molecules present antigenic peptides for CD8+ T-cell recognition. Prior to cell surface expression, proper... Halenius,Anne,Hauka,... - 《Journal of Virology》 被引量: 79发表: 2011年 Insights into MHC class I antigen processing gained from la...
Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity peptides in the MHC-I groove (editing). While X-ray and cryo-EM snapshots of MHC-I in complex with TAPBPR and Tapasin,...