Classical MHC class I molecules (also known as MHC class Ia molecules) are extremely polymorphic. They are the main molecules that present pathogen-derived peptides to T cells, and they also interact with natural killer (NK)-cell receptors. By contrast, non-classical MHC class I molecules (al...
MHC class I moleculesdoi:10.1007/3-540-29662-X_1823Major histocompatibility complex class ISpringer Berlin Heidelberg
1Introduction MHC class Iand II molecules are peptide-presenting proteins.MHC class Imolecules interact with CD8+T cells, thus mediatingcellular immunityby destruction of virus-infected cells.MHC class IImolecules interact with CD4+T cells, thereby facilitating the activation of macrophages or B cells...
NKG2A, NKG2C, NKG2D;Table 1), that are capable of interacting with a broad spectrum of different ligands. Many of these are non-classical MHC I molecules, such as MHC class I chain-related (MIC) A and MICB and the UL16-binding ...
MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.HLA and MHC antibodies play a significant role ...
摘要: Simultaneous triggering of NK1.1 and MHC class I on NK cells gives a higher Ca2+ flux response compared to triggering the NK1.1 receptor alone. The data suggest a novel costimulatory role for MHC class I molecules on NK cell responses.关键词:...
1. MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection. [J] . Routes JM, Ryan JC, Ryan S, International immunology. . 2001,第10期 机译:表达腺病毒E1A的肿瘤细胞上的MHC I类分子抑制NK细胞杀伤,但不抑制NK细胞介导...
States that major histocompatibility complex (MHC) class I molecules present peptides derived from the endogenous protein pool to cytotoxic T lymphocytes, ... Spies,T.,Cerundolo,... - 《Nature》 被引量: 254发表: 1992年 Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung...
Expression of adenovirus E1A gene products in tumor cells enhances NK cell lysis in vitro and NK-mediated rejection in vivo, despite increasing class I molecules on tumor cells. It is unclear why the increased expression of MHC class I molecules does not appear to confer resistance to killing ...
The expression of class I Major Histocompatibility Complex (MHC) molecules by early trophoblast of intraspecific and , interspecific mule and extraspecific -in-conceptuses was determined using a monoclonal antibody (291) in a anti-immunohistochemical technique. Most non-invasive allantochorion of , and...