HLA workshopsAntigen processingThis chapter focuses on the discovery of the Major Histocompatibility Complex (MHC) in mice (H-2) and in humans (HLA), and on the role played by the International HLA Workshops in the analysis and characterization of this complex genetic system. The early days of...
Indeed, the down-regulation or total loss of expression of MHC class I contributes to the evasion of cancer cells from the host immune system by preventing the presentation of peptides to cancer-specific T cells, as well as NK cells. In order to further characterize the relationship between ...
小结 根据癌症不同的类型,在40-70%病例中发现MHCⅠ缺失,不仅是促进肿瘤生长,还使免疫治疗效果不佳,如之前的TCE治疗就因MHCⅠ丢失而产生免疫逃避(T cell-engager:哪些“T cells”在产生应答)。 肿瘤细胞介导MHCⅠ丢失一些机制是可逆或可被绕过的,靶向策略可能需要个性化治疗方案。联合免疫疗法能带来很好的效果,发展...
[5].Gettinger S, Choi J, Hastings K, et al. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017;7(12):1420-1435. doi:10.1158/2159-8290.CD-17-0593 [6].Torrejon DY, Abril-Rodri...
HLA-1 genotype influences response to checkpoint inhibitors Peter Sidaway Research Highlights03 Jan 2018 Nature Reviews Clinical Oncology Volume: 15, P: 66 HLA genotype: good to be different HLA class I homozgosity and loss of heterozygosity are associated with poor response to checkpoint blo...
More recently, the expression of NKG2D has been described also in a small population of CD4+CD28- T cells in patients with autoimmune conditions [6]. In humans, NKG2D recognizes two structurally distinct families of ligands named MHC class I chain-related (MIC) molecules, and the UL16-...
Cancer HLA-A*02:01 VIMPCSWWV Chondromodulin-I Pubmed Scholar Infectious diseases HLA-A*02:01 VLEETSVML CMV IE-1 Pubmed IEDB Scholar Infectious diseases HLA-A*03:01 KLGGALQAK CMV IE-1 IEDB Scholar Infectious diseases HLA-A*24:02 AYAQKIFKI CMV IE-1 IEDB Scholar Infectious diseases HLA...
(MHC) class I in controlling the phagocytic function of macrophages. Our results demonstrated that expression of the common MHC class I component β2-microglobulin (β2M) by cancer cells directly protected them from phagocytosis. We further showed that this protection was mediated by the inhibitory...
MHC presents peptides to T cells leading to initiation of an adaptive immune response in many pathological conditions, such as auto-immunity, cancer, and during infections. While MHC class I molecules generally present peptides to be recognized by the T cell receptor of CD8+ T cells, MHC ...
Journal2017,Trends in Cancer SayuriYoshihama, ...Koichi S.Kobayashi MHC Class I MHC class Imolecules are composed of a polymorphic chain and a non-polymorphic invariantβ chain(B2M) linked by a noncovalent interaction.MHC class Igenes are categorized intoclassical (MHC class Ia)(HLA-A, -B,...