MHC I类分子装配与荷肽:MHC I分子与抗原肽的结合过程简称荷肽,粗面内质网中新合成的MHC I类分子α链进入光面内质网,在辅助蛋合帮助下折叠成立体结构并与β2m结合。当抗原肽通过TAP进入内质网时,合适的肽就与MHC I类分子结合。与肽结合形成肽-MHC I类分子复合物后,稳定地附着在内质网膜上,进一步通过高尔基体胞吐...
产品名称: MHC Class I (HLA-A, HLA-B, HLA-C) SKU: ab-131-060 产品型号: SKU: ab-131-060产品展商: AffinityImmuno产品文档: 无相关文档 简单介绍 MHC Class I (HLA-A, HLA-B, HLA-C) SKU: ab-131-060 $224.25 MHC Class I (HLA-A, HLA-B, HLA-C) SKU: ab-131-060 的详细介绍 MHC...
组织相容性复合体蛋白1抗体,Anti-MHC class I/HLA-A 厂家直销,质量稳定、价格可靠,全国免费运输。 上海沪峥专业供应各类一抗、二抗、标记二抗、抗原等多种抗体产品,主要用于石蜡切片免疫组化,冰冻切片免疫组化, Eli
This protein is an MHC class I alloantigen, which is involved in antigen presentation to T cells expressing CD3/TCR and CD8. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high...
This protein is an MHC class I alloantigen, which is involved in antigen presentation to T cells expressing CD3/TCR and CD8. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performan...
The presence of dozens of class I loci, including the well known HLA-A, B, and C loci, as well as a number of other class I genes, both functional and nonfunctional, are revealed. Of these, only HLA-A, B, and C are shown definitively to present peptide antigens to CD8+ T cells...
英文名称MHC class I 中文名称组织相容性复合体蛋白1抗体 别名MHC-1; MHC1; MHC 1; A 28; A 9; Aw 24; Aw 68; CLASS I HISTOCOMPATIBILITY ANTIGEN; H2 K1; H2K; HLA A; HLAA; HLA-A; HLA class I histocompatibility antigen A 1 alpha chain; HLA class I histocompatibility antigen A 11 alpha...
Zhou Y et al. Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2025840118. Jongsma MLM et al. The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Me...
根据基因的位置和功能,主要组织相容性复合体分为三类,分别为MHC class I,MHC class II,MHC class III. MHC class I(MHC I):位于一般细胞表面上,可以提供一般细胞内的一些状况,比如该细胞遭受病毒感染,则将病毒外膜碎片之氨基酸链(peptide)透过MHC提示在细胞外侧,可以供杀手CD8+ T细胞等辨识,以进行扑杀。 MHC cl...
既要识别抗原肽，也要识别自身MHC分子的多态性部分，此现象即MHC限制性（MHC restriction）。指T细胞在识别Ag递呈细胞传递的抗原信息时，必须先识别递呈细胞上的MHC抗原类型，如Th细胞识别MHC-Ⅱ类分子，而CTL细胞只识别MHC-Ⅰ类分子，之后才获取抗原信息的现象。