MHC class I MHC class II proteins MHC class II 1 Present on the surface of all nucleated cells Present on the surface of antigen presenting cells such as macrophages, B cells, dendritic cells etc. 2 Mainly interact with cytotoxic T cells Mainly interact with helper T cells 3 Encoded by ...
β2m,β2微球蛋白;MIIC,MHC II隔离体(MHC class II compartment);TCR,T细胞受体。 抗原加工和呈递的主要作用之一是将细胞内和细胞外的蛋白表达与免疫系统进行通信,这一过程被称为免疫监视。通过T淋巴细胞仔细查看胞内蛋白的表达(CD+8 T细胞对应HLA-I分子)或外源性抗原的呈递(CD+8 T细胞对应HLA-I分子交叉呈递...
MHC I类分子装配与荷肽:MHC I分子与抗原肽的结合过程简称荷肽,粗面内质网中新合成的MHC I类分子α链进入光面内质网,在辅助蛋合帮助下折叠成立体结构并与β2m结合。当抗原肽通过TAP进入内质网时,合适的肽就与MHC I类分子结合。与肽结合形成肽-MHC I类分子复合物后,稳定地附着在内质网膜上,进一步通过高尔基体胞吐...
MHC-II的肽结合裂隙与MHC-I类的裂隙差异主要在于两端开放，允许肽从裂隙中延伸出来。一般来说，MHC-II...
MHC class II基因最广为人知的别称是HLA基因。HLA基因分为HLA class II和HLA class I两个大类,其中HLA class II基因包括HLA-DP(DPα1和DPβ1),HLA-DQ(DQα1和DQβ1)以及HLA-DR(DRα1和DRβ1)。HLA基因在人类免疫系统中扮演着抗原呈递和免疫调节的重要角色。 2. DC基因家族: DC (differentiation cluste...
The structure ofMHC class IImolecules is similar to that of class I molecules, as illustrated inFig. 10.2A. Class II molecules are composed of a heterodimer of two proteins encoded within the MHC locus. These two proteins, designated α and β, each contain two extracellular domains (and thu...
The expression of HLA class I and class II antigens in corneas from normal donors and patients with quiescent herpetic keratitis was investigated using specific monoclonal antibodies. Keratocytes from diseased corneas showed aberrant expression of HLA class I and class II (DR, DP and DQ) antigen...
在众多MHC基因中,MHC Class II基因备受关注。MHC Class II基因主要表达于抗原递呈细胞(如树突状细胞、巨噬细胞等),它们在免疫应答中扮演着关键角色。 【二、MHC Class II基因的作用与功能】 MHC Class II基因编码蛋白质产物,这些产物具有抗原递呈功能。它们能够将病原体或其他外来抗原递呈给CD4+T细胞,从而激发免疫...
MHC class I- and class II-restricted processing and presentation of microencapsulated antigens. Vaccine. 1999;17:1047-56.Men Y, Audran R, Thomasin C, Eberl G, Demotz S, Merkle HP, Gander B, Corradin G. 1999. MHC class I- and class II-restricted processing and pre- sentation of ...
MHC Class I/H-2 Rat mAb,来自阿拉丁,Aladdin的所有抗体均在WB、IP、IHC、ChIP或ICC/IF中进行了验证,并在小鼠、大鼠、人、酿酒酵母、非洲爪蟾、拟南芥中进行了测试…