对于所有9个MHC-II分子（6个HLA-DR、1个HLA-DP、1个HLA-DQ和1个小鼠I-Ed），我们成功地产生了具...
TCR在T细胞表面通常以多个相同拷贝(>1×105)表达。其中,CD8+T细胞主要识别由I类MHC分子呈递的抗原肽,而CD4+T细胞则主要识别由II类MHC分子呈递的抗原肽。其中:人类MHC→HLA复合体→编码HLA抗原;小鼠MHC→H-2复合体→编码H2抗原。 图1 DC细胞介导的pMHC呈递...
Antigen discovery technologies have largely focused on major histocompatibility complex (MHC) class I-restricted human T cell receptors (TCRs), leaving methods for MHC class II-restricted and mouse TCR reactivities relatively undeveloped. Here we present
1. How many possible MHC class I molecules could you make if you were heterozygous at each locus? What if you were heterozygous at 2 loci? If heterozygous at each locus, 6 unique MHC I molecules can be made. If at 2 loci, 4 unique molecules. How many possible MHC class II molecules...
Description: The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion-encoded glycoproteins (I-A b, I-A d, I-A q, I-E d, I-E k, not I-A f, I-A k, or I-A s). It detects a polymorphic determinant pres...
Class I and Class II MHC TheMHC class Imolecule is aheterodimercomposed of a heavy chain of about 350amino acids, which is encoded within the MHC locus, and a light chain of about 100 amino acids, β2microglobulin, which is encoded elsewhere. The structure of an MHC class I molecule is...
MHC Class I Monomers ProM1™ MHC Class I Monomers, biotin labeled ProM2® MHC Class II Monomers ProM2® MHC Class II Monomers, biotinylated ProMap® -Chinese ProMap® T Cell Proliferation Assays ProMix™ Peptide Pools ProMix™ Peptide Pools – Chinese (混合肽) ProPresent – ...
Negative Control / CLIPH-2 IAbN02KPVSKMRMATPLLMQAHuman class II-associated invariant chain peptide (CLIP) 103-117 Negative Control / CLIPH-2 IAdN02MPVSQMRMATPLLMRPMurine class II-associated invariant chain peptide (CLIP) 86-100 Negative Control / CLIPH-2 IAg7N02LPVSQMRMATPLLMRPMurine class...
Here we show, using transcriptomic profiling of susceptible versus non-susceptible cells in combination with genome-wide CRISPR–Cas9 screening, that the major histocompatibility complex class II (MHC-II) human leukocyte antigen DR isotype (HLA-DR) is an essential entry determinant for bat influenza ...
T cell epitopes presented by MHC Class I molecules were predicted by NetMHCPan2.4 binding algorithm. (XLSX 13 kb) Additional file 4: Table S4. Amino acid sequences of predicted MHC Class II molecule HLA DRB1 binding neo-peptides in 147 lung adenocarcinoma patients in this study. (XLSX 503 ...