[2] Radhika M , Yalan Z , Grimmer M R , et al. MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence[J]. 2020. [2] Ogura R , Tsukamoto Y , Natsumeda M , et al. Immunohistochemical...
L.; Donati, G.; Lisotti, A.; Campana, D. Prospective Evaluation of MGMT-Promoter Methylation Status and Correlations with Outcomes to Temozolomide-Based Chemotherapy in Well-Differentiated Neuroendocrine Tumors. Curr. Oncol. 2023, 30, 1381-1394. https://doi.org/10.3390/curroncol30020106 ...
O6-甲基鸟嘌呤DNA甲基转移酶(O6-methylguanine DNA methyltransferase, MGMT)基因启动子甲基化(MGMT promoter methylation, MGMTmet)状态常见于WHO Ⅱ~Ⅳ级胶质瘤中,已有研究发现它可提高胶质瘤对替莫唑胺(temozolomide,TMZ)等烷化剂的敏感性,提示患者具有更长的总生存期,目前已成为预测胶质瘤患者治疗效果及预后的重要...
MGMT基因编码一种重要的DNA修复酶—O6-甲基鸟嘌呤-DNA甲基转移酶,它可修复DNA损伤,抵消烷化剂对肿瘤细胞造成的毒副作用。研究证实,发生MGMT启动子甲基化的脑胶质瘤、小细胞肺癌等患者对替莫唑胺(Temozolomide,TMZ)等烷化剂敏感,且生存期更长[1]。 目前,我司开展MGMT相关检测项目,除了单独检测的“MGMT基...
O6-甲基鸟嘌呤-DNA甲基转移酶(O6-methylguanine- DNA methyltransferase,MGMT)是影响胶质瘤对化疗药物敏感性的重要分子标志物,当MGMT启动子(MGMT promoter,pMGMT)发生甲基化时,MGMT阻碍烷基化类药物损伤肿瘤氨基酸的能力丧失[4-5]。相反,pM...
PROMOTER METHYLATION,MGMT基因突变,PROMOTER METHYLATION基因变异,,mgmt启动子甲基化已被观察到影响多形性胶质母细胞瘤的肿瘤进展。在出现启动子甲基化的患者中,Akylating试剂卡莫司汀已显示出疗效。在缺乏甲基化的患者中,卡莫司汀和MGMT抑制剂O(6)-苄基鸟嘌呤结合可能
Kinslow CJ, Rae AI, Taparra K, Kumar P, Siegelin MD, Grinband J, Gill BJA, McKhann GM, Sisti MB, Bruce JN, Canoll PD, Iwamoto FM, Horowitz DP, Kachnic LA, Neugut AI, Yu JB, Cheng SK, Wang TJC. MGMT promoter methylation predicts overall survival after chemotherapy for 1p/19q...
Brighi, N.; Lamberti, G.; Andrini, E.; Mosconi, C.; Manuzzi, L.; Donati, G.; Lisotti, A.; Campana, D. Prospective Evaluation of MGMT-Promoter Methylation Status and Correlations with Outcomes to Temozolomide-Based Chemotherapy in Well-Differentiated Neuroendocrine Tumors. Curr. Oncol. 20...
O6-甲基鸟嘌呤DNA甲基转移酶(O6-methylguanine DNA methyltranferase,MGMT)基因启动子甲基化(MGMT promoter methylation,MGMTmet)状态可预测胶质瘤患者对TMZ治疗的敏感性,但其与临床病理学特征的关系及如何更好地预测治疗效果及患者预后尚需深入研...
为了揭开这个谜团,来自相关研究机构的科研人员展开了深入探索,并在《Clinical Epigenetics》期刊上发表了题为 “ConstitutionalMGMTpromoter methylation and risk of incident colon cancer, glioblastoma, and B - cell lymphoma: a nested case–control study in the Women’s Health Initiative” 的论文。他们通过...