MGMT promoter methylation was found to be an independent prognostic factor for survival (hazard ratio: 0.41; p = 0.001). However, these initial results were partly offset by the results of a five-year analysis published by the same group at a later date [ 8 ]. In the latter study,...
Background: MGMT is a DNA repair protein that removes the cytotoxic O6-methylguanine (O6MG) DNA lesions generated by TMZ; thereby, MGMT expression is mechanistically linked to TMZ resistance. However, thus far, there is no effective treatment for these patients with MGMT promoter unmethylated. Th...
MGMT promoter methylation in patients with glioblastoma: is methylation-sensitive high-resolution melting superior to methylation-sensitive polymerase chain reaction assay?doi:10.3171/2017.11.JNS171710Shinji YamashitaKiyotaka YokogamiFumitaka MatsumotoKiyotaka Saito...
MGMT promoter methylation in patients with glioblastoma: is methylation-sensitive high-resolution melting superior to methylation-sensitive polymerase chain reaction assay?O6-methylguanine-DNA methyltransferaseMGMTmethylation-sensitive high-resolution melting
O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important clinical biomarker of newly diagnosed glioblastoma. Previous radiological studies using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion have aimed to predict MGMT methylation status ...
Apparent diffusion coefficient as imaging biomarker for identifying IDH mutation, 1p19q codeletion, and MGMT promoter methylation status in patients with glioma. Gliomas, originating in glial cells of neuroepithelial tissue in the brain parenchyma, are a major cause of death and include glioblastoma,...
P-0267DOSE-DENSE TEMOZOLOMIDE (TMZ) IN PATIENTS WITH ADVANCED CHEMOREFRACTORY COLORECTAL CANCER (CRC) AND MGMT PROMOTER METHYLATIONEBSCO_AspAnnals of Oncology
The MGMT promoter is hypermethylated in U87MG cells while unmethylated in LN18 cells. The anti-cancer effects of selinexor (20 mg/kg, PO, once weekly) and TMZ (50 mg/kg, PO, QDX5, week 1 only) were also tested in a mouse xenograft model of U87MG using different dosing schedules (8...
In this paper we present a small and fast Convolutional Neural Network (CNN) used to predict the presence of MGMT promoter methylation in Magnetic Resonance Imaging (MRI) scans. Our data set is "The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification...
Fabi A, Metro G, Russillo M, Vidiri A, Carapella CM, Maschio M, Cognetti F, Jandolo B, Mirri MA, Sperduti I, Telera S, Carosi M, Pace A (2009) Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation. BMC ...