Currently there is no known treatment for TD (Samie et al., 1987; Miller and Jancovic, 1989; Sethi, 2004). TD developing after discontinuation of long-term metoclopramide is also described (Lavy et al., 1978). Acute dystonic reactions including retrocollis, oculogyric crisis, trismus, ...
Patients with intestinal neuropathy or response to bolus octreotide are more probable long-term responders. The ... Sjogren,W Robert - 《Current Opinion in Rheumatology》 被引量: 324发表: 1996年 Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility...
while relaxing thepylorusand duodenum. Metoclopramide is indicated for nausea and vomiting associated with chemotherapy and as anantiemeticfordogswith parvoviralenteritis. In clinically normal dogs, metoclopramide does not increase gastric emptying and in dogs with gastric dilation andvolvulus, metoclopramide...
Metoclopramide does cross the blood–brain barrier, leading to multiple neurological effects. Common adverse drug reactions associated with metoclopramide therapy include restlessness (akathisia) and focal dystonia. Long term dosing of metoclopramide may be the most common cause of tardive dyskinesia, whi...
Drug for gastroparesis has been most successful withcisapride,metoclopramide,domperidone, orerythromycin. Cisapride ormetoclopramidehave been used for long-term oral therapy, whileerythromycinis usually reserved for intravenous use in the acutely ill patient. Gastrointestinal promotility agents may improve the...