. Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for ...
. Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for ...
. Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for ...
To determine whether a mixture for intravenous perfusion containing tramadol (5 mg/ml), ranitidine (1.5 mg/ml), ketorolac (1.5 mg/ml) and metoclopramide (0... H Watanabe,T Watanabe,H Suzuya,... - Farm Hosp 被引量: 2发表: 2003年 Metoclopramide Pretreatment for Prevention of Pain on Propo...
16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing ...
Premedication (45–50 min prior to anaesthesia) consisted of either acepromazine (0.1 mg/kg, IM) plus 1 mg/kg (IM) pethidine (ACP + P) or their combination with metoclopramide which was given 5–7 min either before or after the other drugs. Studies of continuous tracings taken for 1 ...
Abstract— The effect of cisplatin on plasma peptide YY (PYY) and 5-hydroxytryptamine (5-HT) concentrations was determined in conscious dogs (n = 6 per gro... MR Perry,J Rhee,WL Smith - 《Journal of Pharmacy & Pharmacology》 被引量: 40发表: 1994年 Optimum anti-emetic therapy for cispla...
Extrapolated from the short elimination half-life of metoclopramide indogs(90 minutes), frequent intermittent dosing or delivery by a constant rate infusion (CRI) is necessary. Empirical dosing in cats is 0.2 to 0.4 mg/kg subcutaneously or orally every 8 hours or 1 to 2 mg/kg/day as a CR...
The effect of metoclopramide (0.4 mg/kg, IM) on lower oesophageal sphincter pressure (LOSP) and barrier pressure (BrP) were studied manometrically (non-perfused with strain gauge pressure transducer) in 30 dogs undergoing ovariohysterectomy. Premedication (45–50 min prior to anaesthesia) consisted...
By random allocation, half the dogs received metoclopramide (M) as an IV bolus (0.4 mg kg –1 ) and then infusion (0.3 mg kg –1 hour –1 ), the others received equivalent volumes of saline (S). To measure esophageal pH a sensor-tipped catheter was placed with the tip 5–7 cm ...