Extrapolated from the short elimination half-life of metoclopramide indogs(90 minutes), frequent intermittent dosing or delivery by a constant rate infusion (CRI) is necessary. Empirical dosing in cats is 0.2 to
Studies of continuous tracings taken for 1 min at 10 min interval during surgery have suggested that if metoclopramide is given prior to ACP + P it can restore BrP to a significantly (Unpaired "t" test) higher level than when it is given subsequently or not used at all. It seemed that...
Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for ...
16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing ...
dogs with ED50values of 6.17 and 0.45 mg/kg, respectively.1,2Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively).3Formulations containing metoclopramide have been used...
(300mg, iv). The effects of metoclopramide seem to be independent of either the type of anaesthetic or the premedicant used but for optimum effect may need to be given towards the end of the operation. Controlled trials have demonstrated that 10mg intramuscular metoclopramide is significantly ...
被引量: 10发表: 2015年 Effect of Gongronema latifolium on gastric emptying in healthy dogs. latifolium in capsules at 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively, while the prokinetic group ingested 0.5 mg/kg capsules of metoclopramide... O Sylvester,Ogbu,K Kenneth,... - 《Wor...
Although metoclopramide is sometimes recommended for endoscopic procedures to facilitate passage of the endoscope through the pylorus, this effect was not confirmed in a well-controlled study of the effect of pharmacological agents on the ease of endoscopic intubation in dogs. In fact, increased antral...
A preliminary in vivo evaluation of POE/MTC formulations on dogs is also reported. Access through your organization Check access to the full text by signing in through your organization. Access through your organization Section snippets Materials Materials were purchased as follows: trimethyl orthoace...
The plasma half-life of metoclopramide in the dog is approximately 90 min. In contrast to humans, in whom glucuronidation and sulfate conjugation are the major metabolic pathways,N-demethylation is more important for metoclopramide metabolism in dogs. ...