First, a meta-analysis of reduction in NTD recurrence and occurrence risk with periconceptional folic acid supplementation is presented. Second, an overview of the complex folate metabolism is given. Third, SNPs for genes involved in folate and homocysteine metabolism that have been studied in ...
Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging, including cancer and cardiovascular and neurological diseases. Evidence is accumulating that dietary factors in utero modulate disease risk in later life. Although folic acid is a key ...
DNA Methylation in Folbp1 Knockout Mice Supplemented with Folic Acid during Gestation Periconceptional folic acid supplementation has been shown to prevent up to 70% of neural tube and other birth defects in humans; however, the mechanism is... Finnell,Richard,H.,... - 《Journal of Nutritio...
Folic acid,as a molecule for taking one-carbon unit,play an important role in vivo,especially it takes part in methylation. 叶酸作为一碳单位携带分子,在机体内发挥着非常重要的作用,它所参与的甲基化作用与蛋白质的合成紧密相关,本文对叶酸影响蛋白质的合成过程做了比较全面的综述,旨在阐明叶酸在蛋白质合...
Keywords: neural tube defects; DNA methylation; histone methylation; m6A RNA methylation; folic acid 1 Introduction Abnormal development of the central nervous system (CNS) caused by neural tube defects (NTDs), such as anencephaly, spina bifida, and encephalocele, is a major contributor to stillbir...
Jing Yuan Fang,Shu Dong Xiao.Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis[J]. Journal of Gastroenterology .2003(9)Fang JY, Xiao SD (2003) Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in ...
Metabolic substances such as SAM, folic acid [211] and vitamin B12 [212] are necessary for DNA and chromatin alterations, serving as methyl donors for DNA and histone methylation. According to a study conducted by Lan et al., folic acid supplementation significantly reduced the toxic effects of...
3.2. National Programs for NTDs Prevention There are three potential approaches for the delivery of folic acid to the general population: improvement of dietary habits, fortification of food and use of supplements [59]. In 1992 the CDC recommended the use of periconceptional FA supplementation of...
Folic acid from the diet or supplements must be converted to this active form, 5-MTHF, before it can be used in the body in the methylation cycle. Unfortunately, approximately 60% of people in the United States have a genetic mutation that makes it challenging for their bodies to create en...
Folic acid,as a molecule for taking one-carbon unit,play an important role in vivo,especially it takes part in methylation. 叶酸作为一碳单位携带分子,在机体内发挥着非常重要的作用,它所参与的甲基化作用与蛋白质的合成紧密相关,本文对叶酸影响蛋白质的合成过程做了比较全面的综述,旨在阐明叶酸在蛋白质合...