这些个体不能完成将合成叶酸(Folic acid)转化为活性形式L-甲基叶酸(Methylfolate)的最终代谢步骤。 注意,最后一步(最后一个黑色箭头)需要MTHFR酶和维生素B2将5,10亚甲基四氢呋喃转化为L-甲基叶酸。 这种情况下,合成叶酸(Folic acid)的补充对你无益,从长远来看可能是有害的。 总之:任何摄入的合成叶酸(Folic acid)...
Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human HealthCarboni, LorenaIntegrative Medicine: A Clinician's Journal
Alternative Medicine Review Volume 10, Number 3 September 2005 Monograph Folic Acid After ingestion, the process of conversion of folic acid to the metabolically active coenzyme forms is relatively complex. Synthesis of the active forms of folic acid requires several enzymes, adequate liver and ...
Folic acid is a B-group vitamin; another name for it is vitamin B9. Folic acid has several important functions in the body including the maintenance of a normoblastic bone marrow, the synthesis of nucleic acids, the conversion of carbohydrates into glucose, the utilization of fats and protein...
Folic acid is the form most commonly used in fortification and supplements because it is generally more bioavailable, more stable, and less complex than food folates. The appearance of methylfolate is largely due to developments in the science of human genetics, and the discovery of a particular...
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(2) Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase. The low activity of this enzyme in the human liver, combined ...
Levomefolic acid (L-5-methylfolate), the biological active form of folate, can be transported across the blood brain barrier (BBB) and reach the central nervous system to be used for neural transmitter synthesis. However, D-5- methylfolate, its racemic counterpart, may inhibit regulatory ...
. A large percentage of the population has genetic mutations which slows the conversion of food folates and folic acid to the needed form of the folate – methylfolate. The mutation: MTHFR or methylenetetrahydrofolate reductase (confused yet? – yes it’s difficult). Free folic acid circulating...