Methylation levels atCRHR1, DRD2andLSD1genes was significantly higher in cases with respect to controls (p<0.01,p=0.03 andp=0.03, respectively). Frontline health professionals experienced more negative effects on mental health during COVID-19 pandemic than non-frontline healthcare workers. ...
“Methylation plays the same role in mental health in everyone. Every piece of Biology is all based on carbon. Our body is primarily composed of carbon and hydrogen with a few other things thrown in,” said Chris Masterjohn. “Methylation in the scientific literature is often referred to as ...
when DNA methylation is altered as a result of developmental mutations or environmental risk factors, such as drug exposure and neural injury, mental impairment is a common side effect
Learning and memory are two of the fundamental cognitive functions that confer us the ability to accumulate knowledge from our experiences. Although we use these two mental skills continuously, understanding the molecular basis of learning and memory is very challenging. Methylation modification of DNA ...
studies and subsequently to the development of DNA methylation-based predictors across a wide range of health-related applications, from the identification of risk factors or exposures, such as age and smoking, to early detection of disease or progression in cancer, cardiovascular and neurological ...
This work was supported by a grant from the Simons Foundation (SFARI 137603 to D.E. Arking) and by the National Institute of Mental Health Autism Centers of Excellence Network Grant MH100027. Availability of data and materials Data are being submitted to the NIMH Data Archive (https://ndar...
The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis Undernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic mechanisms and thus ... H Eichenauer,U Ehlert - 《Cli...
There is growing recognition of the importance of non-sequence-based regulatory variation in health and disease. Building on the hypothesis that epigenomic dysregulation is important in the etiology and progression of AD neuropathology10, we and others have identified DNA methylation differences in severa...
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. Eur Respir J. 2019;54(6):1901507. Article PubMed Google Scholar Yang IV, et al. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol. 2015;136(1):69–80. ...
Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims Teenage suicide is a major public health concern, but its neurobiology is not very well understood. Stress and major mental disorders are major risk factor... GN Pandey,X Ren...