Medicinal ChemistryDrug DesignAn overview on the paper The Methylation Effect in Medicinal Chemistry, published by Chemical Reviews and written by brazilian researchers Eliezer J. Barreiro, Arthur E. K眉mmerle and Carlos A. M. Fraga. In this overview, some examples of methyl effect, discussed in...
Aminomethylation of compo... BS Holla,B Veerendra,MK Shivananda,... - 《European Journal of Medicinal Chemistry》 被引量: 600发表: 2003年 Biological activity of palladium(II) and platinum(II) complexes of the acetone Schiff bases of S-methyl- and S-benzyldithiocarbazate and the X-ray ...
Still overwhelmed by the discovery of pervasive genome transcription, in the most recent years we have been hit by a counter-wave of pervasive translation. In the last decades, the∼20,000 proteins encoded by our genome (https://www.gencodegenes.org/human/stats_45.html) have been the und...
et al. Editing DNA methylation in the mammalian genome. Cell 167, 233–247. e217 (2016). Article CAS PubMed PubMed Central Google Scholar Yue, Y. et al. Extensive germline genome engineering in pigs. Nat. Biomed. Eng. 5, 134–143 (2021). Article CAS PubMed Google Scholar ...
[5]. Within each class of compounds, the variations around the basic chemical skeleton essentially concern the degrees of oxidation, hydroxylation, methylation, glycosylation and the possible connections to other molecules (primary metabolites such as carbohydrates, lipids, proteins, or phenolic secondary...
CDK6 is frequently overexpressed in various cancer types and functions as a positive regulator of the cell cycle and as a coregulator of gene transcription. We provide evidence that CDK6 is involved in the process of DNA methylation, at least in ALL. We observe a positive correlation of CDK...
release of active drugs into the brain is facilitated [103]. For drugs that contain alcohol or carboxylic acid groups, ester is the most commonly used prodrug form. Amines, on the other hand, can be transformed into amides, imines, azo, amine methylation, or other forms to prepare prodrugs...
It is metabolized by cytochrome P450 via opening of morpholine ring due to being rich in electrons [57]. Similar to reboxetine, viloxazine 25 is a selective norepinephrine reuptake inhibitor and used as a potent antidepressant. It is extensively metabolized by N-methylation of morpholine ring ...
Living organisms post-translationally modify amino acids by acylation, glycosylation, methylation, phosphorylation, sulfation, etc., to extend the chemical repertoire beyond the 20 canonical amino acids. ncAAs expand the scope of these modification reactions to the vast repertoire of organic methodologies...
Whole-genome sequencing of patients with immunodeficiency has led to the discovery that PI3Kγ and PI3Kδ both play important roles in immune cell maintenance. Recent advances in medicinal chemistry now allow specific isoform targeting and thus have provided new insights into methods to augment antitumo...