peptides in a biological sample (endogenously produced, or exogenously administered as drugs). Peptidomics employs techniques of genomics, modern proteomics, state-of-the-art analytical chemistry and innovative
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This includes the integrative analysis of genomic and proteomic data for exome annotation in the form of gene discovery and gene model refinement (Proteomics Aiding Genome Annotation); protein level detection of single amino acid variants (SAAVs)1 , insertions, deletions, alternative splice junctions...
(F J Silva & A Latorre) Comparative Mechanisms for Transcription and Regulatory Signals in Archaea and Bacteria (A Mart铆nez-Antonio & J Collado-Vides) Computational Techniques for Orthologous Gene Prediction in Prokaryotes (M Poptsova) Computational Elucidation of Operons and Uber-Operons (P Dam...
In one study, six loci that are important for yield and productivity were targeted, and the engineered lines displayed increased fruit size, fruit number and fruit lycopene accumulation [157]. In prokaryotes, CRISPR/Cas are a family of DNA sequences found in bacteria and archaea genomes and as...
Phylogenetic profiling encompasses an important set of methodologies for in silico high throughput inference of functional relationships between genes. The simplest profiles represent the distribution of gene presence-absence in a set of species as a seq
in prokaryotes and eukaryotic proteins show a nonlinear relationship between the degree of disordered protein structure and thermal stability. The data indicate that evolutionary conservation of protein complexes is reflected by similar thermal stability of their proteins, and we show examples in which ...
In principle, CRISPR/Cas9 systems are nucleic acid-targeting defensive tools of prokaryotes, whose operation is exploited to edit mammalian genomic materials and control transcriptional regulation of endogenous genes; in turn, these genes can be used to control molecular routines in tissue regeneration ...
The distance-based phylogenetic method is fast and remains the most popular one in molecular phylogenetics, especially in the big-data age when researchers often build phylogenetic trees with hundreds or even thousands of leaves. A distance-based method has two components: the evolutionary distance ma...
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site w