Gene prediction is a comprehensive algorithm that deals with gene modeling, upstream modeling, start site initiation and overlapping genes issues. Despite the need for accurate gene prediction in prokaryotes, little effort has been dedicated to the comparison of various modeling strategies. This article...
Gene duplication is a normal evolutionary process. If there is no selective advantage in keeping the duplicated gene, it is usually reduced to a pseudogene and disappears from the genome. However, some paralogs are retained. These gene products are likel
To counter this argument, we compared the predictions of our method in two genomes (H. influenzae and H. pylori) to those of the web-based version of GeneMark.hmm 2.1 for prokaryotes http://opal.biology.gatech.edu/GeneMark/gmhmm2_prok.cgi, which generated results using two models; the '...
Experimental techniques for identification of essential genes (EGs) in prokaryotes are usually expensive, time-consuming and sometimes unrealistic. Emerging in silico methods provide alternative methods for EG prediction, but often possess limitations in
Microbial gene prediction is a well studied, and some would say solved, problem, but the truth is that there is still much room for improvement, especially in understanding how translation initiation mechanisms work in prokaryotes. Existing methods for bacterial and archaeal gene prediction include th...
We present a www server for AUGUSTUS, a novel software program for ab initio gene prediction in eukaryotic genomic sequences. Our method is based on a generalized Hidden Markov Model with a new method for modeling the intron length distribution. This method allows approximation of the true intron...
In eukaryotes, the RCC1 superfamily has been divided into five subgroups based on the structures of other domains in the proteins [49]. On the other hand, three subfamilies of diverse RCC1-like repeat proteins have been reported in both prokaryotes and eukaryotes [50], namely, proteins ...
Recently, a computational tool to regulate many genes simultaneously in prokaryotes has been developed. This tool designs gRNAs with orthogonal Cas9 handles that can target between 1 and 20 input sequences48. Future computational tools made specifically for gRNA arrays should incorporate retroactive effec...
纪志梁-厦门大学-Prediction of Adverse Drug Reactions药物副反应 via Gene Regulation Network 热度: 英汉对照分子生物学导论 Chapter 7 Regulation of Gene Expression in eukaryotes 热度: 分子生物学-Lecture8 gene regulation in prokaryotes 热度: I nthedesert,vasttractsoflandarelifeless, ...
Munch R, Hiller K, Grote A, Scheer M, Klein J, Schobert M, Jahn D: Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes. Bioinformatics. 2005, 21 (22): 4187-4189. 10.1093/bioinformatics/bti635. [http://bioinformatics.oxfordjournals.org/cgi/content/...