To ensure the "quality" of animal experiment results.It is stipulated in Chinese Pharmacopoecia that the clean and /or SPF animals should be used for qualitycontrol of biological products. This is necessary to ensure the accuracy of animal testing result and to avoidrepetition of animal test...
INSILICO METHODS: AN ALTERNATIVE METHOD TO ANIMAL TESTING International Journal of Pharmacy & Life SciencesPrachand, SumeetPatidar, PoojaThagele, PankajMehzabeen
spleens are removed, and a single cell suspension of 5 × 106cells/ml is prepared. Mitogens are titrated (four replicates/group) in 0.1 ml/well and 0.1 ml of the cell suspension is added. Plates are incubated at 37 °C in 5 % CO2in air for 48–60 h and for another 8...
byWageningen University Making more use of in-vitro testing, the upcoming 21st-century scientific fields known as 'omics' sciences and developing smart test strategies can clearly reduce the amount of essential animal testing. This is the view of Professor Bennard van Ravenzwaay in his inaugural s...
The contribution of animal-based methods in toxicology to hazard identification of chemicals in food and diet is discussed. The importance of first applying existing technical and chemical knowledge to the design of safety testing programs for food chemicals is emphasised. There is consideration of ...
Non-animal sensitization testing: State-of-the-art Predictive tests to identify the sensitizing properties of chemicals are carried out using . In the European Union timelines for phasing out many standard ... RJ Vandebriel,HV Loveren - 《Critical Reviews in Toxicology》 被引量: 115发表: 2010...
Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a transgenic animal and the effects of the administering are determined; the transgenic animal includes an added gen...
Methods for evaluating the performance of automated tools are presented (i.e., receiver operating characteristics and precision-recall) and challenges with classifying animal sounds are discussed. Jeanette A. Thomas (deceased) contributed to this chapter while at the Department of Biological Sciences, ...
Significant phylogenetic codivergence between plant or animal hosts (H) and their symbionts or parasites (P) indicate the importance of their interactions on evolutionary time scales. However, valid and realistic methods to test for codivergence are not fully developed. One of the systems where poss...
The orally sensitized mouse model is a useful tool to address the in vivo allergenicity of novel milk formulas and demonstrates the safety of hydrolysates produced under high-pressure conditions. 展开 关键词: β-lactoglobulin high-pressure hydrolysates hypoallergenic animal model ...