Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may alter dementia onset. Mixed results are emerging from prior observational studies. To address this complexity, we deploy a causal inference approach accounting for the competing risk of death in emulated clinic...
Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing 3 (NLRP3) is a signaling pathway that is involved in inflammatory cascades, cell survival and the immune response. NLRP3 is activated by cellular damage, oxidative stress, and other factors that stimulate the ...
Metformin activates AMPK; AMPK activation has been shown to have anti-inflammatory effects by sup- pressing nuclear factor kappa B (NF-kB) with subsequent inhibition of the overexpression of IL-1β (Xiang et al. 2019; Zhang et al. 2020). According to our results, we found that ...
Necroptosis, a form of programmed cell death, accounts for many inflammations in a wide range of diseases. Diet-induced obesity is manifested by low-grade inflammation in the mediobasal hypothalamus (MBH), and microglia are implicated as critical responsive components for this process. Here, we d...
Nowadays, there are many classes of anti-diabetic medication; nevertheless their role in the therapy of diabetes with heart failure is still undefined. Some drugs used for diabetes have been associated with increased rate of hospitalization for HF, despite its neutral or positive effect on overall ...
Efforts to repurpose metformin, the first choice as an oral treatment of type 2 diabetes, as an antimetabolite drug, reinforce the interest in understanding food and drug interactions and the expected toxic effects caused by a change in dose range. Acknowledgments: We apologize to the many ...
In conclusion, our work demonstrates that the anti-tumoral action of metformin is due to the inhibition of glutaminase and autophagy and could be used to improve the efficacy of chemotherapy. Keywords: autophagy; cell death; glutaminase; metabolism; molecular rehabilitation. 1. Introduction Autophagy ...
prostate cancer;metformin;hydroxytyrosol;anti-tumour actions 1. Introduction Prostate cancer (PCa) constitutes the second most frequently diagnosed malignancy and the fifth leading cause of cancer-related mortality among males globally [1]. While the initial diagnosis often identifies tumours with low risk...
The studies were carried out in compliance with the generally agreed normative ethical standards for the use and treatment of laboratory an- imals as set out in the Guidelines of the European Community; EEC Directive 86/609/EEC of 24 November 1986 [26]. Rats were acclimatized to the ...