HypothesisIn the clinical follow-up of metastatic breast cancer patients, semi-automatic measurements are performed on 18FDG PET/CT images to monitor the evolution of the main metastatic sites. Apart from being time-consuming and prone to subjective approximations, semi-automatic tools cannot make ...
a, Box plots showing the distribution of the number of CTCs collected at ZT4 or ZT16 via cardiac puncture or tumor draining vessel (TDV) in the NSG-CDX-BR16 breast cancer mouse model (n = 4; P = 0.0286 for all). b, Representative bioluminescence images of lungs from NSG-CD...
Immunocytochemical or molecular assays allow the detection of single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of metastasis. Results from recently reported studies suggest that circulating tumor cell (CTC...
On contrast-enhanced T1-weighted images, the metastatic lesions are typically moderate to marked nodular-enhancing lesions or ringlike enhancing lesions with central nonenhancement. With advances in CT and MRI in detecting intracranial lesions and the longer survival of patients with breast canc...
Metastatic human breast cancer to the spine produces mechanical hyperalgesia and gait deficits in rodentsdoi:10.1016/j.spinee.2017.04.009Metastases to the spine are a common source of severe pain in cancer patients. The secondary effects of spinal metastases include pain, bone fractures, hypercalcemia...
The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won both competitions in the grand challenge, obtaining an area under...
Radovich M (2012) Next-generation sequencing in breast cancer: translational Sci and clinical integration. Pharmacogenomics 13(6):637–639. doi:10.2217/12.18 CrossRef Swanton C, Burrell RA, Futreal PA (2011) Breast cancer genome heterogeneity: a challenge to personalized medicine? Breast Cancer ...
Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or
Abstract Metastasis accounts for most cancer-associated deaths; yet, this complex process remains poorly understood, particularly the relationship between distant metastasis and primary site-derived cells. Here, we modified the classical MMTV-PyMT breast carcinoma model to trace the fate of mammary-deriv...
Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and