approximately 20-30% of women first diagnosed with early stage breast cancer will go on to develop metastatic disease in their lifetime. In addition, of the estimated 26,300 Canadian women that will
Oncology Insights into breast cancer metastasis| understanding the roles of transcription factorsmicroRNAs and the tumor microenvironment UNIVERSITY OF CALIFORNIASAN FRANCISCO Zena WerbGabriele BergersJay Debnath ChouJonathanMost cancer-related deaths are attributable to metastatic disease, a multistep process ...
Purpose: To investigate the effect of understanding their own disease by patients with metastatic breast cancer on their survival potential after being informed by their physician. Patientsandmethods: Two hundred and fourteen women with metastatic breast cancer who participated in a multi-institutional, ...
Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst. 2011;103:1513–28. CAS PubMed PubMed Central Google Scholar Chen J, Feng WL, Mo WJ, Ding XW, Xie SN. Expression of integrin-binding protein Nischarin in metastatic breast cancer....
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have
Tamoxifen has been used for over 40 years to treat early, locally advanced and metastatic ER-positive breast cancer; however, patients develop resistance ... PG Ersan,O Saatci,O Tarman,... - 《Experimental & Molecular Therapeutics》 被引量: 0发表: 2019年 New understanding of the mechanism ...
metastatic breast cancer cells, suggesting that breast cancer metastases may be initiated by stem-like cells. Paired-end transcriptome sequencing identified unique patterns of gene expression in breast cancer stem cells compared to other breast cancer cell types that may regulate the effects of oncogene...
metastatic breast cancer cell line [285]. CpG-STAT3ASO, an antisense oligonucleotide combined with radiotherapy could activate the mature of human DCs, M1 polarization of macrophages and promoted CD8+T cell recruitment, thereby suppressing UM-SCC1 tumor growth [286]. Due to the excellent efficacy ...
[72]. Membrane deformation also induces increased ATP releasing, and the released ATP in turn suppresses deformation-induced apoptosis of vascular metastatic breast cancer cells [67]. Under the altered mechanical force, ATP consumption is also enhanced to maintain the dynamics of actin cytoskeleton [...
(NCT00887198)147. In a phase II trial for women with triple negative, AR+ locally advanced or metastatic breast cancer (NCT01842321), treatment with abiraterone acetate and prednisone also provided benefit for some patients148. Of 138 patients assessed for the trial, 53 (37.6%) had AR+ TNBC...