Globally, cancer stands as the predominant cause of mortality, with the World Health Organization attributing over 90% of cancer-related deaths to metastasis. Annually, ~18 million individuals receive a cancer diagnosis, and of these, an estimated 10–15% will manifest metastases. Prevalent cancers ...
In particular, cuproptosis can act as the immunogenic cell death (ICD) evoker to release damage-associated molecular patterns (DAMPs), and then improve tumor immunogenicity24,25. Despite the fact that cuproptosis combined with immunotherapy have shown some benefit for lung metastasis, cuproptosis-...
A schematic overview of the whole process is given in Figure 1. Presence of metastasis was significantly associated with tumour size (P<0.0001). The following metastatic sites were identified according to the data in the autopsy reports: lung, bone and bone marrow, lymph node (regionary, juxta...
Oncolytic virotherapy (OVT) is a promising emerging cancer immunotherapy that leverages the natural ability of certain replicating viruses to infect and preferentially lyse tumor cells while leaving non-tumor cells intact [10]. The viruses are sourced from naturally occurring viruses in the environment ...
National Inpatient Sample (NIS) to explore patients who have lung cancer as the primary diagnosis. Additionally, we identified evidence of metastasis, as recorded by ICD-10-CM. Adjusted odds ratios (aORs) for specified outcomes were calculated through multivariable logistic and linear regression ...
Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare, with an estimated annual incidence of approximately 3.65/10,000 people per year [1, 2]. The natural disease progression of pancreatic neuroendocrine tumors can lead to local lymph node, liver, lung, and bone metastases. Among these,...
35 In contrast to the bone metastatic signature described by Kang et al., which was identified in pre-clinical models and then shown to predict bone metastasis in humans, Savci-Heijink et al. identified a 15-gene signature predictive of bone metastasis from among over 500 primary breast ...
Notch 2 is a receptor belonging to the Notch family. It can be activated when it binds to its ligands, leading to the cleavage and release of the Notch2 intracellular domain (N2ICD) [12]. The N2ICD can translocate to the nucleus, where it inter- acts with the transcription factor RBPJ...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Bone is the most common site of metastasis, and although low proliferation and immunoediting at the early stage make existing treatment modalities less effective, the microenvironment-inducing behaviour could be a target for early intervention. Here we r