We aimed to evaluate the impact of MDT on clinical outcomes of pts with nccRCC.Methods:We reviewed our institutional database (So Paulo State Cancer Institute, University of So Paulo) to identify pts with ICD-C64 (kidney cancer) with nccRCC. Electronic medical records were reviewed to ...
Bone is the most common site of metastasis, and although low proliferation and immunoediting at the early stage make existing treatment modalities less effective, the microenvironment-inducing behaviour could be a target for early intervention. Here we r
The study was conducted in accordance with the Helsinki Declaration (revised in 2013). We studied all elderly PC patients with LM from 2010 to 2020. According to the International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) was used to classify the histologic types (CC: ...
(+) completely halted metastasis to the lungs, whereas other groups showed various degrees of metastatic nodules in pulmonary tissues (Fig.8b). Analysis of post-treatment tumors revealed negligible ICD induction by P-BS-CM1 → P-PS-CM2 (−) (Fig.8c). Conversely, P-BS-CM1 → ...
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain of cancer biology have shed light on the molecular aspects of thi...
Breast cancer is apt to metastasize to bone, lung, liver, and brain preferentially. Among the common metastatic sites, bone metastasis accounts for 30–60%, brain metastasis accounts for 4–10%, liver metastasis accounts for 15–32% and lung metastasis accounts for 21–32% [3]. Lung ...
[10]. The viruses are sourced from naturally occurring viruses in the environment and selected based on their innate ability to induce immunogenic cell death (ICD) in cancer cells, with their tumor selectivity enhanced through genetic engineering or specific viral vectors to promote replication, ...
In particular, cuproptosis can act as the immunogenic cell death (ICD) evoker to release damage-associated molecular patterns (DAMPs), and then improve tumor immunogenicity24,25. Despite the fact that cuproptosis combined with immunotherapy have shown some benefit for lung metastasis, cuproptosis-...
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain of cancer bio
In addition to the canonical SMAD pathway, TGF-b receptors can initiate other intracellular pathways via either phosphorylation or direct interaction with signalling intermediates; these so-called non-SMAD signalling pathways include several branches that involve phosphatidylinositol kinase (PI3K)/AKT, ...