Kagiya (2015) noted that osteolytic bone metastasis frequently occurs in the later stages of breast, lung, and several other cancers. Osteoclasts, the only cells that resorb bone, are hijacked by tumor cells, which break down bone remodeling systems. As a result, osteolysis occurs and may ca...
macrophages, then processed and presented to adaptive immune cells, stimulating an antigen-specific immune response toward a broad-spectrum of solid tumors13,19. Recently, some chemotherapeutics, such as oxaliplatin (Oxa), doxorubicin, and mitoxantrone have also been demonstrated to induce ICD21,22. ...
Figure 2. Enforced Expression of Jagged1 in Breast Cancer Promotes Osteolytic Bone Metastasis (A) Kaplan-Meier bone metastasis-free survival curve of mice inoculated with control or JAG1 OE SCP28 cells (n = 10). (B) Normalized BLI signals of bone metastases of mice from each experimental gr...
Each participant'smedical recordwas analyzed for history of previous fragility fractures of the hip, spine,proximal humerus, anddistal radius, either as coded ICD-10, narrated medical records, X-rays, computed tomography (CT), or magnetic resonance imaging (MRI). When available,vertebral fracture...
When these parameters were simplified to a mitotic count of either <10 mitoses or ≥10 mitoses /1.7mm2 and necrosis as either present or absent, they were predictive of both metastasis and disease-free survivals by univariate analysis (Mitotic count: p=0.0001; p=0.001 and Necrosis: p=0.013,...
miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis. Bone 2013; 52: 532–539. 135 Hassan MQ, Gordon JA, Beloti MM et al. A network connecting Runx2, SATB2, and the miR-23a,27a,24–2 cluster regulates the osteoblast differentiation program. Proc ...
Chimeric Antigen Receptor (CAR) T cell therapy is an accepted standard of care for relapsed/refractory B cell malignancies. However, the high cost of existing industry-driven centralized production makes this therapy unaffordable in low and middle-income countries. Decentralized or point of care manuf...
In the nucleus, Notch ICD (intracellular domain) binds specific transcription factors and recruits transcriptional co-activators to induce the expression of bHLH family of genes.152Notch pathway is active in the early stages of osteoblast differentiation, also by acting on Runx2-dependent osteogenic ge...
cancers Article Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study Miaochun Zhong 1,2,†, Farhana Zerin Khan 3,†, Xianghong He 4, Lingfei Cui 5, Kefeng Lei 5,...