Kagiya (2015) noted that osteolytic bone metastasis frequently occurs in the later stages of breast, lung, and several other cancers. Osteoclasts, the only cells that resorb bone, are hijacked by tumor cells, which break down bone remodeling systems. As a result, osteolysis occurs and may ca...
Patients with primary and bone metastatic breast cancer have significantly reduced survival and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the limited response rate of immunotherapy for breast cancer, effective
When these parameters were simplified to a mitotic count of either <10 mitoses or ≥10 mitoses /1.7mm2 and necrosis as either present or absent, they were predictive of both metastasis and disease-free survivals by univariate analysis (Mitotic count: p=0.0001; p=0.001 and Necrosis: p=0.013,...
When evidence of fracture was marked in the ICD-10 or narrated medical records, relevant imaging was again checked to confirm the diagnosis. Fracture from high-energy trauma was excluded. 2.2.3. Bone densitometry DXA scans of all subjects were performed using HORIZON A Hologic bone densitometry ...
Comparison of minimally-invasive fibular supporting of T-type with traditional bloody iliac flap metastasis for osteonecrosis of the femoral head at ARCO stage II. Heliyon. 2022;8:e12212. https://doi.org/10.1016/j.heliyon.2022.e12212. Article CAS PubMed PubMed Central Google Scholar Wang H,...
In the nucleus, Notch ICD (intracellular domain) binds specific transcription factors and recruits transcriptional co-activators to induce the expression of bHLH family of genes.152Notch pathway is active in the early stages of osteoblast differentiation, also by acting on Runx2-dependent osteogenic ge...
Direct CNS involvement in MM often presents as leptomeningeal myelomatosis (LMM), intraparenchymal metastasis, cranial nerve involvement, or radiculopathy [54, 95, 117]. Though conventional wisdom would suggest CNS involvement is seen later during the disease, most patients present relatively early ...
In the nucleus, Notch ICD (intracellular domain) binds specific transcription factors and recruits transcriptional co-activators to induce the expression of bHLH family of genes.152Notch pathway is active in the early stages of osteoblast differentiation, also by acting on Runx2-dependent osteogenic ge...
miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis. Bone 2013; 52: 532–539. 135 Hassan MQ, Gordon JA, Beloti MM et al. A network connecting Runx2, SATB2, and the miR-23a,27a,24–2 cluster regulates the osteoblast differentiation program. Proc ...
Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence. Breast 2016, 30, 156–171. [CrossRef] [PubMed] 34. Plotkin, L.; Speacht, T.L.; Donahue, H.J. Cx43 and mechanotransduction in bone. Curr. Osteoporos. Rep. ...