Mutations in genes encoding APC subunits (such as CDC26 and APC2) have a much more severe effect. Little or no sister separation occurs in apc2-1 or cdc26Δ mutants at 37°C (Zachariae et al. 1998). Remarkably, the kinetics of sister separation are very similar, if not identical, in...
1. Introduction Fluorescence In-Situ Hybridization (FISH) is an indispensable molecular cytogenetic technique for diagnosis of both inherited and acquired chromosomal abnormalities at a much higher resolution than conventional karyotyping [1-10]. Novel FISH based techniques are commonly used in diagnosis ...