Embryonic stem (ES) cells are derived from the inner cell mass of the embryonic blastocyst. These cells can be maintained indefinitelyin vitrowithout loss of differentiation potential, and when reimplanted into a host embryo, they give rise to progenies that differentiate into all tissues. However,...
Cytokines, growth factors, signaling lipids, mRNAs, and miRNAs secreted by MSCs enables tissue-resident stem cells to undergo differentiation into specific cell types. Tissue-resident stem cells include pluripotent, very small embryonic-like stem cells (VSELs) and progenitors [spermatogonial (SSCs), ...
Apoptosis is an evolutionarily conserved cell death process that plays a significant role in embryonic development and tissue homeostasis [81]. Show abstract Engineered exosomes and composite biomaterials for tissue regeneration 2024, Theranostics Show abstract Establishing an hTERT-driven immortalized ...
Although cell-surface antigens of MSCs have been extensively explored, thereis no conclusive evidence that unique stem cells markers are associated with these adult cells. Therefore the aim of thisstudy was to examine expression of embryonic stem cell markers 展开 ...
The term "mesenchymal" refers to the embryonic origin of the cells, specifically cells that arise from the mesoderm germ layer. The mesoderm germ layer is one of the three primary germ layers that form during the early stages of embryonic development. ...
(EMT), is central to many aspects of embryonicmorphogenesisand adult tissue repair, as well as a number of disease states. The reverse process whereby mesenchymal cells coalesce into an epithelium is a “mesenchymal–epithelial transition” (MET). Understanding the molecules that regulate this ...
(MSCs) have emerged as the most promising therapeutic candidates in regenerative medicine, as they are more ethically and socially acceptable and show less tumorigenicity than embryonic stem cells. Because of their multilineage differentiation potential, the protective effects of MSC transplantation were ...
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic ef
Very Small Embryonic Like Stem Cells MI: Myocardial Infarction ECM: Extracellular Matrix 5-Aza: 5- Azacytidine DMSO: Dimethyl Sulfoxide MSC-Exo: MSC derived Exosomes References Feric, N.T., Radisic, M. (2016) Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered...
During the last decade, stem cell therapy, as a new technology, is widely developed for bone regeneration in patients with osteoporosis. MSCs are the most extensively used stem cell type for this disease [128]. Studies in animal models have revealed that both allogeneic and autologous BM-MSCs ...