一、流行性脑膜炎ACWY适合人群 1、前往香港、美国、英国、加拿大及澳洲等地升学或长期居留的儿童; 2、前往沙特阿拉伯参加朝观、小朝或前往朝观地带工作人士包括2岁以上儿童; 3、前往高发区(非洲撒哈拉沙漠以南地区,包括塞内加尔、埃塞俄比亚、安哥拉等国家)旅游人士; 二、两款流行性脑膜炎疫苗区别 A、美国辉瑞Pfize...
2011年4月,FDA批准了4价脑膜炎球菌结合疫苗(Men ACWY-D)(Menactra,赛诺菲巴斯德)用于9～23月龄的儿童,作为两剂式的基础免疫.对于2岁的儿童不建议接种脑膜炎球菌多糖疫苗(MPSV4),因为这个年龄组的免疫原性低且保护作用的时间短.ACIP(免疫实施咨询委员会)的脑膜炎球菌疫苗工作组审查了Men ACWY-D在9～23月龄健康...
建议肺炎球菌2011年4月,FDA批准了4价脑膜炎球菌结合疫苗(Men ACWY-D)(Menactra,赛诺菲巴斯德)用于9～23月龄的儿童,作为两剂式的基础免疫.对于2岁的儿童不建议接种脑膜炎球菌多糖疫苗(MPSV4),因为这个年龄组的免疫原性低且保护作用的时间短.ACIP(免疫实施咨询委员会)的脑膜炎球菌疫苗工作组审查了Men ACWY-D在9...
Background:Neisseria meningitidis serogroups A, B, C, W and Y cause most meningococcal disease worldwide. An investigational MenABCWY vaccine combining serogroup B antigens and a meningococcal ACWY CRM Methods:We conducted this observer-blind study (NCT02140762) and its extension (NCT02285777) in ...
Vesikari, B. Sandner, F. Martinón-Torres, G. Muzsay, A. Forsten, et al. Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) vs. a licensed quadrivalent meningococcal tetanus toxoid-conjugate vaccine in meningococcal vaccine-naïve and ...
Indeed, polysaccharide vaccines are B-cell-dependent antigens, are not immunogenic in infants and young children, induce antibodies that last for 3–5 years only and, most important, they are not able to induce immunological memory, so have little or no effect on nasopharyngeal carriage and in...
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Many bacterial components are able to stimulate the adaptive human immune response. Porins can activate the translation of NF-κB in the nucleus of B and DCs, while class I Pilin E induces highly specific antibodies (Abs) and class II induces cross-reacting Abs. Furthermore, complement cascade...
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