The recent expansion of the hyper-virulent serogroup W strain (cc11) led to an adolescent MenACWY conjugate vaccination program initiated in 2015 for those 14 years of age [86]. Hence, a quadrivalent meningococcal conjugate (ACWY-CRM or ACWY-TT) is administered among these age groups. For tho...
Background In August, 2015, the UK implemented an emergency adolescent immunisation programme with the meningococcal ACWY conjugate vaccine to combat a national outbreak of meningococcal group W (MenW) disease due to a hypervirulent ST-11 complex strain, which is currently causing regional and ...
those 15–24 years old [21]. Importantly, MenB rates in December 2020 were higher than pre-pandemic levels, especially among 15- to 24-year-olds [21]. This is of notable concern because France lacks a mandatory MenB vaccination program for adolescents/young adults (although vaccination is r...
A, B, C, W and Y strains, percentage of participants whose sera is effective against ≥70% of the strains tested using hSBA at 1 month after different vaccination schedules, and the percentage of patients achieving ≥4-fold rise in hSBA titres from baseline for ACWY and MenB test strains...
While highly effective quadrivalent capsule polysaccharide vaccines against Nm serogroups ACWY are being used [4], the development of vaccines against Nm serogroup B [MenB) has proven difficult. This is due to the similarity of the group B capsule to the polysialic acid found on the surface of...
Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambiadoi:10.1056/NEJMoa2214924BackgroundAn effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-...
In December 2013 Bexsero® became available in Germany for vaccination against serogroup B meningococci (MenB). In August 2015 the German Standing Comm
Several European countries recommend childhood vaccination with vaccines conferring protection against serogroup B, serogroup C and/or serogroups ACWY IMD [11, 12]. Of the five serogroups that cause most disease worldwide (B/A/C/W/Y), serogroup B currently causes most cases of IMD in Europe [...
While the ACWY conjugated vaccine, Menactra, was approved in 2015 in Japan, routine vaccination has never been conducted in Japan due to the very low incidence of IMD. However, the next international event after the Tokyo 2020 Olympic games in 2021 will be Expo 2025 in Osaka. Therefore, we...
Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial. Lancet. 2014;384(9960):2123-31. doi:10.1016/S0140-6736(14)60842-4. PMID:25145775....